Journal article
A narrative review of converging evidence addressing developmental toxicity of pyrethroid insecticides
Critical reviews in toxicology, Vol.ahead-of-print(ahead-of-print), pp.1-18
11/03/2022
DOI: 10.1080/10408444.2022.2122769
PMCID: PMC9930199
PMID: 36345971
Abstract
Pyrethroid insecticides are broadly used in agriculture and household products throughout the world. Exposure to this class of insecticides is widespread, and while generally believed to be safe for use, there is increasing concern regarding their effects on neurodevelopment. Due to the critical roles that molecular targets of pyrethroids play in the regulation of neurodevelopment, particular focus has been placed on evaluating the effects of in utero and childhood pyrethroid exposure on child cognition and behavior. As such, this narrative review synthesizes an assessment of converging study types; we review reports of neonatal pyrethroid levels together with current epidemiological literature that convergently address the risk for developmental toxicity linked to exposure to pyrethroid insecticides. We first address studies that assess the degree of direct fetal exposure to pyrethroids in utero through measurements in cord blood, meconium, and amniotic fluid. We then focus on the links between prenatal exposure to these insecticides and child neurodevelopment, fetal growth, and other adverse birth outcomes. Furthermore, we assess the effects of postnatal exposure on child neurodevelopment through a review of the data on pediatric exposures and child cognitive and behavioral outcomes. Study quality was evaluated individually, and the weight of evidence was assessed broadly to characterize these effects. Overall, while definitive conclusions cannot be reached from the currently available literature, the available data suggest that the potential links between pyrethroid exposure and child neurodevelopmental effects deserve further investigation.
Details
- Title: Subtitle
- A narrative review of converging evidence addressing developmental toxicity of pyrethroid insecticides
- Creators
- Benjamin A. Elser - University of IowaBenjamin Hing - University of IowaHanna E. Stevens - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Critical reviews in toxicology, Vol.ahead-of-print(ahead-of-print), pp.1-18
- DOI
- 10.1080/10408444.2022.2122769
- PMID
- 36345971
- PMCID
- PMC9930199
- NLM abbreviation
- Crit Rev Toxicol
- ISSN
- 1040-8444
- eISSN
- 1547-6898
- Publisher
- Taylor & Francis
- Grant note
- DOI: 10.13039/100000066, name: National Institute for Environmental Health Sciences, award: NIEHS/NIH P30 ES005605; name: University of Iowa’s Center for Health Effects of Environmental Contamination; name: Pappajohn Biomedical Institute
- Language
- English
- Electronic publication date
- 11/03/2022
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984313159902771
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