Journal article
A neurologist's guide to safe use of immunomodulatory therapies
Seminars in neurology, Vol.34(4), pp.467-478
09/2014
DOI: 10.1055/s-0034-1390395
PMID: 25369442
Abstract
Increased understanding of the pathogenesis of immune-mediated neurologic conditions with concomitant development of new therapeutic agents modulating various aspects of the immune system has resulted in the use of innovative therapies in the treatment of these diseases. These novel immunomodulatory therapeutic regimens also augment the potential for complications, including severe adverse effects.In this review, the authors address practical issues regarding management of patients with neuroimmunological conditions treated with immunomodulatory therapies, including glucocorticoids, methotrexate, azathioprine, mycophenolate, cyclophosphamide, rituximab, tumor necrosis factor-α inhibitors, and intravenous immunoglobulins. Particular focus is placed on their infectious and noninfectious adverse effects, contraindications, safety monitoring, risk surveillance, and preventive strategies in clinical practice.
Details
- Title: Subtitle
- A neurologist's guide to safe use of immunomodulatory therapies
- Creators
- Ivana Vodopivec - Harvard Medical School, Boston, MassachusettsEli M Miloslavsky - Harvard Medical School, Boston, MassachusettsCamille N Kotton - Harvard Medical School, Boston, MassachusettsTracey A Cho - Harvard Medical School, Boston, Massachusetts
- Resource Type
- Journal article
- Publication Details
- Seminars in neurology, Vol.34(4), pp.467-478
- Publisher
- United States
- DOI
- 10.1055/s-0034-1390395
- PMID
- 25369442
- ISSN
- 0271-8235
- eISSN
- 1098-9021
- Language
- English
- Date published
- 09/2014
- Academic Unit
- Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984070341302771
Metrics
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