Journal article
A new angle on RGS Protein modulation
Trends in pharmacological sciences (Regular ed.), Vol.46(9), pp.829-831
09/2025
DOI: 10.1016/j.tips.2025.07.012
PMID: 40752996
Abstract
Most drug discovery efforts targeting Regulator of G-protein signaling (RGS) proteins, inhibiting their activity is the end-goal. A recent article by Aryal et al (2025) presents a novel strategy to stabilize RGS2 by blocking its degradation via the ubiquitin-proteasomal system rather than inhibiting its function—a shift from developing small molecule inhibitors targeting RGS proteins to modulate GPCR signaling.
Most drug discovery efforts targeting Regulator of G-protein signaling (RGS) proteins, inhibiting their activity is the end-goal. A recent article by Aryal et al (2025) presents a novel strategy to stabilize RGS2 by blocking its degradation via the ubiquitin-proteasomal system rather than inhibiting its function—a shift from developing small molecule inhibitors targeting RGS proteins to modulate GPCR signaling.
Details
- Title: Subtitle
- A new angle on RGS Protein modulation
- Creators
- David L. Roman - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Trends in pharmacological sciences (Regular ed.), Vol.46(9), pp.829-831
- DOI
- 10.1016/j.tips.2025.07.012
- PMID
- 40752996
- NLM abbreviation
- Trends Pharmacol Sci
- ISSN
- 0165-6147
- eISSN
- 1873-3735
- Publisher
- Elsevier Ltd
- Language
- English
- Electronic publication date
- 08/2025
- Date published
- 09/2025
- Academic Unit
- Pharmacy; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984945084802771
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