A new automated NaCl based robust method for routine production of gallium-68 labeled peptides

Michael K Schultz; Dirk Mueller; Richard P Baum; G.Leonard Watkins; Wouter A.P Breeman

doi:10.1016/j.apradiso.2012.08.011

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A new automated NaCl based robust method for routine production of gallium-68 labeled peptides

Journal article

Open access

Peer reviewed

A new automated NaCl based robust method for routine production of gallium-68 labeled peptides

Michael K Schultz, Dirk Mueller, Richard P Baum, G.Leonard Watkins and Wouter A.P Breeman

Applied radiation and isotopes, Vol.76, pp.46-54

06/2013

DOI: 10.1016/j.apradiso.2012.08.011

PMCID: PMC5506834

PMID: 23026223

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http://doi.org/10.1016/j.apradiso.2012.08.011View

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Abstract

A new NaCl based method for preparation of gallium-68 labeled radiopharmaceuticals has been adapted for use with an automated gallium-68 generator system. The method was evaluated based on 56 preparations of [68Ga]DOTATOC and compared to a similar acetone-based approach. Advantages of the new NaCl approach include reduced preparation time (<15min) and removal of organic solvents. The method produces high peptide-bound % (>97%), and specific activity (>40MBqnmole−1 [68Ga]DOTATOC) and is well-suited for clinical production of radiopharmaceuticals. ► A NaCl based automated production of Ga-68-radiopharmaceuticals is described. ► Using 5M NaCl for pre-purification of 68Ga eliminates the need for organic solvents. ► The method provides for high efficiency, specific activity, and radiochemical purity. ► The new method eliminates the need for the quality control by gas chromatography.

NaCl

Ion Exchange

DOTA peptides

Gallium-68

Radiopharmaceuticals

Positron emission tomography

Details

Title: Subtitle: A new automated NaCl based robust method for routine production of gallium-68 labeled peptides
Creators: Michael K Schultz - Department of Radiology, The University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
Dirk Mueller - Zentralklinik Bad Berka, Department of Nuclear Medicine, PET Center, 99437 Bad Berka, Germany
Richard P Baum - Zentralklinik Bad Berka, Department of Nuclear Medicine, PET Center, 99437 Bad Berka, Germany
G.Leonard Watkins - Department of Radiology, The University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
Wouter A.P Breeman - Department of Nuclear Medicine, Erasmus MC Rotterdam, 3015CE Rotterdam, The Netherlands
Resource Type: Journal article
Publication Details: Applied radiation and isotopes, Vol.76, pp.46-54
DOI: 10.1016/j.apradiso.2012.08.011
PMID: 23026223
PMCID: PMC5506834
NLM abbreviation: Appl Radiat Isot
ISSN: 0969-8043
eISSN: 1872-9800
Publisher: Elsevier Ltd
Language: English
Date published: 06/2013
Academic Unit: Radiology; Stead Family Department of Pediatrics; Radiation Oncology
Record Identifier: 9984047709602771

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