A new look at TCF and beta-catenin through the lens of a divergent C. elegans Wnt pathway

Bryan T Phillips; Judith Kimble

doi:10.1016/j.devcel.2009.07.002

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A new look at TCF and beta-catenin through the lens of a divergent C. elegans Wnt pathway

Journal article

Open access

Peer reviewed

A new look at TCF and beta-catenin through the lens of a divergent C. elegans Wnt pathway

Bryan T Phillips and Judith Kimble

Developmental cell, Vol.17(1), pp.27-34

07/2009

DOI: 10.1016/j.devcel.2009.07.002

PMCID: PMC4236000

PMID: 19619489

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Abstract

The canonical Wnt/beta-catenin pathway is extensively characterized, broadly conserved, and clinically important. In this review, we describe the C. elegans Wnt/beta-catenin asymmetry pathway and suggest that some of its unusual features may have important implications for the canonical Wnt/beta-catenin pathway.

Animals

beta Catenin - genetics

beta Catenin - metabolism

Caenorhabditis elegans - physiology

Caenorhabditis elegans Proteins - genetics

Caenorhabditis elegans Proteins - metabolism

Cell Polarity

Gene Expression Regulation

Humans

Mitogen-Activated Protein Kinases - genetics

Mitogen-Activated Protein Kinases - metabolism

Models, Molecular

Phylogeny

Protein Structure, Tertiary

Signal Transduction - physiology

TCF Transcription Factors - genetics

TCF Transcription Factors - metabolism

Wnt Proteins - genetics

Wnt Proteins - metabolism

Details

Title: Subtitle: A new look at TCF and beta-catenin through the lens of a divergent C. elegans Wnt pathway
Creators: Bryan T Phillips - Department of Biochemistry and Howard Hughes Medical Institute, University of Wisconsin-Madison, Madison, WI 53706-1544, USA. btphillips@wisc.edu
Judith Kimble
Resource Type: Journal article
Publication Details: Developmental cell, Vol.17(1), pp.27-34
DOI: 10.1016/j.devcel.2009.07.002
PMID: 19619489
PMCID: PMC4236000
ISSN: 1534-5807
eISSN: 1878-1551
Grant note: F32 GM075598-03 / NIGMS NIH HHS Howard Hughes Medical Institute F32 GM075598 / NIGMS NIH HHS
Language: English
Date published: 07/2009
Academic Unit: Biology
Record Identifier: 9984217538302771

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