Journal article
A new model to estimate insulin resistance via clinical parameters in adults with type 1 diabetes
Diabetes/metabolism research and reviews, Vol.33(4), pp.e2880-n/a
05/2017
DOI: 10.1002/dmrr.2880
PMID: 28029212
Abstract
Insulin resistance (IR) is a risk factor to assess the development of micro- and macro-vascular complications in type 1 diabetes (T1D). However, diabetes management in adults with T1D is limited by the difficulty of lacking simple and reliable methods to estimate insulin resistance. The aim of this study was to develop a new model to estimate IR via clinical parameters in adults with T1D.
A total of 36 adults with adulthood onset T1D (n = 20) or childhood onset T1D (n = 16) were recruited by quota sampling. After an overnight insulin infusion to stabilize the blood glucose at 5.6 to 7.8 mmol/L, they underwent a 180-minute euglycemic-hyperinsulinemic clamp. Glucose disposal rate (GDR, mg kg
min
) was calculated by data collected from the last 30 minutes during the test. Demographic factors (age, sex, and diabetes duration) and metabolic parameters (blood pressure, glycated hemoglobin A
[HbA
], waist to hip ratio [WHR], and lipids) were collected to evaluate insulin resistance. Then, age at diabetes onset and clinical parameters were used to develop a model to estimate lnGDR by stepwise linear regression.
From the stepwise process, a best model to estimate insulin resistance was generated, including HbA
, diastolic blood pressure, and WHR. Age at diabetes onset did not enter any of the models. We proposed the following new model to estimate IR as in GDR for adults with T1D: lnGDR = 4.964 - 0.121 × HbA
(%) - 0.012 × diastolic blood pressure (mmHg) - 1.409 × WHR, (adjusted R
= 0.616, P < .01).
Insulin resistance in adults living with T1D can be estimated using routinely collected clinical parameters. This simple model provides a potential tool for estimating IR in large-scale epidemiological studies of adults with T1D regardless of age at onset.
Details
- Title: Subtitle
- A new model to estimate insulin resistance via clinical parameters in adults with type 1 diabetes
- Creators
- Xueying Zheng - Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, ChinaBin Huang - Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, ChinaSihui Luo - Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, ChinaDaizhi Yang - Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, ChinaWei Bao - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USAJin Li - Third Affiliated Hospital of Sun Yat-sen UniversityBin Yao - Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, ChinaJianping Weng - Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, ChinaJinhua Yan - Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, China
- Resource Type
- Journal article
- Publication Details
- Diabetes/metabolism research and reviews, Vol.33(4), pp.e2880-n/a
- Publisher
- England
- DOI
- 10.1002/dmrr.2880
- PMID
- 28029212
- ISSN
- 1520-7552
- eISSN
- 1520-7560
- Grant note
- DOI: 10.13039/501100014219, name: National Science Fund for Distinguished Young Scholars, award: 81025005; name: 863 project, award: 2012AA02A509; name: Sun Yat-sen University Clinical Research 5010 Program, award: 2007030; name: National Health and Family Planning Commission Foundation for public welfare industry research project, award: 201502011
- Language
- English
- Date published
- 05/2017
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9983995062702771
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