Journal article
A new naturally occurring GABAA receptor subunit partnership with high sensitivity to ethanol
Nature neuroscience, Vol.10(1), pp.40-48
12/10/2006
DOI: 10.1038/nn1813
PMID: 17159992
Abstract
According to the rules of GABAA receptor (GABAAR) subunit assembly, α4 and α6 subunits are considered to be the natural partners of δ subunits. These GABAARs are a preferred target of low, sobriety-impairing concentrations of ethanol. Here we demonstrate a new naturally occurring GABAAR subunit partnership: δ subunits of hippocampal interneurons are coexpressed and colocalized with α1 subunits, but not with α4, α6 or any other α subunits. Ethanol potentiates the tonic inhibition mediated by such native α1/δ GABAARs in wild-type and in α4 subunit–deficient (Gabra4−/−) mice, but not in δ subunit–deficient (Gabrd−/−) mice. We also ruled out any compensatory upregulation of α6 subunits that might have accounted for the ethanol effect in Gabra4−/− mice. Thus, α1/δ subunit assemblies represent a new neuronal GABAAR subunit partnership present in hippocampal interneurons, mediate tonic inhibitory currents and are highly sensitive to low concentrations of ethanol.
Details
- Title: Subtitle
- A new naturally occurring GABAA receptor subunit partnership with high sensitivity to ethanol
- Creators
- Joseph GlykysZechun PengDev ChandraGregg E HomanicsCarolyn R HouserIstvan Mody
- Resource Type
- Journal article
- Publication Details
- Nature neuroscience, Vol.10(1), pp.40-48
- DOI
- 10.1038/nn1813
- PMID
- 17159992
- ISSN
- 1097-6256
- eISSN
- 1546-1726
- Language
- English
- Date published
- 12/10/2006
- Academic Unit
- Neurology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984020650002771
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