Journal article
A new outcome measure for LUTS: Symptoms of Lower Urinary Tract Dysfunction Research Network Symptom Index-29 (LURN SI-29) questionnaire
Neurourology and urodynamics, Vol.38(6), pp.1751-1759
08/2019
DOI: 10.1002/nau.24067
PMCID: PMC6660359
PMID: 31225927
Abstract
To develop a representative, self-report assessment of lower urinary tract symptoms (LUTS) for men and women, the symptoms of Lower Urinary Tract Dysfunction Research Network Symptom Index-29 (LURN SI-29). Women and men seeking treatment for LUTS at one of six academic medical centers in the US were assessed at baseline, 3-month and 12-month intervals. Twelve-month data on 78 LURN SI-29 items were analyzed among 353 women and 420 men using exploratory factor analysis (EFA), with factor structure confirmed using confirmatory factor analysis (CFA). Internal consistency, reliability, and validity of the five developed scales were evaluated by assessing correlations with the American Urological Association Symptom Index (AUA-SI), the genitourinary pain index (GUPI), and the Pelvic Floor Distress Inventory-20 (PFDI-20), and by examining expected sex differences in scores. EFA results (n = 150 women; 150 men) produced an interpretable eight-factor solution, with three of the factors comprised of dichotomous items addressing LUTS-associated sensations. The remaining five factors, confirmed with CFA in an independent sample of 473 participants, produced five scales: incontinence, urgency, voiding difficulty, bladder pain, and nocturia. Subscales and total LURN SI-29 scores were correlated as expected with AUA-SI, GUPI, and PFDI-20. LURN SI-29 scores also performed as expected in differentiating men from women based upon clinically expected differences, with men reporting more voiding difficulties and nocturia, and women reporting more urgency and incontinence. The LURN SI-29 questionnaire has the potential to improve research and clinical outcome measurement for both men and women with LUTS.
Details
- Title: Subtitle
- A new outcome measure for LUTS: Symptoms of Lower Urinary Tract Dysfunction Research Network Symptom Index-29 (LURN SI-29) questionnaire
- Creators
- David Cella - Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IllinoisAbigail R Smith - Arbor Research Collaborative for Health, Ann Arbor, MichiganJames W Griffith - Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IllinoisKathryn E Flynn - Medical College of Wisconsin, Milwaukee, WisconsinCatherine S Bradley - Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa, Iowa City, IowaBrenda W Gillespie - Department of Biostatistics, University of Michigan, Ann Arbor, MichiganZiya Kirkali - National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MarylandPooja Talaty - NorthShore University Health System, Glenview, IllinoisJ Eric Jelovsek - Department of Obstetrics and Gynecology, Duke University, Durham, North CarolinaBrian T Helfand - NorthShore University Health System, Glenview, IllinoisKevin P Weinfurt - Duke University Medical Center, Durham, North CarolinaLURN Study Group
- Resource Type
- Journal article
- Publication Details
- Neurourology and urodynamics, Vol.38(6), pp.1751-1759
- DOI
- 10.1002/nau.24067
- PMID
- 31225927
- PMCID
- PMC6660359
- NLM abbreviation
- Neurourol Urodyn
- ISSN
- 0733-2467
- eISSN
- 1520-6777
- Publisher
- United States
- Grant note
- U01 DK100017 / NIDDK NIH HHS U01 DK100011 / NIDDK NIH HHS U01 DK097779 / NIDDK NIH HHS K23 DK110417 / NIDDK NIH HHS UL1 TR001422 / NCATS NIH HHS U01 DK097780 / NIDDK NIH HHS U01 DK099879 / NIDDK NIH HHS U01 DK097776 / NIDDK NIH HHS U01 DK097772 / NIDDK NIH HHS U01 DK099932 / NIDDK NIH HHS
- Language
- English
- Date published
- 08/2019
- Academic Unit
- Epidemiology; Obstetrics and Gynecology; Urology
- Record Identifier
- 9983931740602771
Metrics
43 Record Views