Journal article
A new path to migraine
Science (American Association for the Advancement of Science), Vol.385(6704), pp.28-29
07/05/2024
DOI: 10.1126/science.adq3498
PMID: 38963860
Abstract
Migraine pain is believed to result from the activation of pain receptors (nociceptors) after the cortical spreading depression (CSD) that is associated with the aura phase of migraine (1). Previous studies have demonstrated that preclinical CSD events release small molecules through the cerebrospinal fluid (CSF) that activate and sensitize afferent trigeminal fibers within the meninges (2, 3). However, it has been thought that trigeminal ganglia reside “outside” the blood-brain barrier and hence are not directly exposed to CSF (4). On page 80 of this issue, Rasmussen et al. (5) show in a mouse model of migraine that after CSD, subarachnoid CSF carries signals from the cortex directly to cell bodies in the trigeminal ganglia, where they activate nociceptors through a pathway that bypasses meningeal trigeminal afferents. The demonstration that the trigeminal ganglia lies within the blood-brain barrier and the identification of the signals that connect aura and headache may provide a new path for preventing and treating migraine.
Details
- Title: Subtitle
- A new path to migraine
- Creators
- Andrew Russo - University of IowaJeffrey Iliff - VA Northwest Network
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.385(6704), pp.28-29
- DOI
- 10.1126/science.adq3498
- PMID
- 38963860
- NLM abbreviation
- Science
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Publisher
- The American Association for the Advancement of Science
- Language
- English
- Date published
- 07/05/2024
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center
- Record Identifier
- 9984652258202771
Metrics
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