A nonneural miRNA cluster mediates hearing via repression of two neural targets

Binglong Zhang; Hong Duan; Joshua Kavaler; Lu Wei; Daniel F Eberl; Eric C Lai

doi:10.1101/gad.351052.123

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A nonneural miRNA cluster mediates hearing via repression of two neural targets

Journal article

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Peer reviewed

A nonneural miRNA cluster mediates hearing via repression of two neural targets

Binglong Zhang, Hong Duan, Joshua Kavaler, Lu Wei, Daniel F Eberl and Eric C Lai

Genes & development, Vol.37(21-24), pp.1041-1051

12/18/2023

DOI: 10.1101/gad.351052.123

PMCID: PMC10760640

PMID: 38110249

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Abstract

We show here that mir-279/996 are absolutely essential for development and function of Johnston's organ (JO), the primary proprioceptive and auditory organ in Drosophila. Their deletion results in highly aberrant cell fate determination, including loss of scolopale cells and ectopic neurons, and mutants are electrophysiologically deaf. In vivo activity sensors and mosaic analyses indicate that these seed-related miRNAs function autonomously to suppress neural fate in nonneuronal cells. Finally, genetic interactions pinpoint two neural targets (elav and insensible) that underlie miRNA mutant JO phenotypes. This work uncovers how critical post-transcriptional regulation of specific miRNA targets governs cell specification and function of the auditory system.

Johnston's organ

Drosophila

neuron

hearing

microRNA

Details

Title: Subtitle: A nonneural miRNA cluster mediates hearing via repression of two neural targets
Creators: Binglong Zhang - Developmental Biology Program, Sloan Kettering Institute, New York, New York 10065, USA
Hong Duan - Developmental Biology Program, Sloan Kettering Institute, New York, New York 10065, USA
Joshua Kavaler - Colby College
Lu Wei - Developmental Biology Program, Sloan Kettering Institute, New York, New York 10065, USA
Daniel F Eberl - Department of Biology, University of Iowa, Iowa City, Iowa 52242, USA
Eric C Lai
Resource Type: Journal article
Publication Details: Genes & development, Vol.37(21-24), pp.1041-1051
DOI: 10.1101/gad.351052.123
PMID: 38110249
PMCID: PMC10760640
NLM abbreviation: Genes Dev
eISSN: 1549-5477
Grant note: DOI: 10.13039/100000001, name: National Science Foundation, award: 2037828; DOI: 10.13039/100000002, name: National Institutes of Health, award: R01-NS083833, R01-GM083300; DOI: 10.13039/100007052, name: Memorial Sloan Kettering Core, award: P30-CA008748
Language: English
Date published: 12/18/2023
Academic Unit: Iowa Neuroscience Institute; Biology
Record Identifier: 9984532207102771

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