Journal article
A novel iris transillumination grading scale allowing flexible assessment with quantitative image analysis and visual matching
Ophthalmic genetics, Vol.39(1), pp.41-45
01/2018
DOI: 10.1080/13816810.2017.1342134
PMCID: PMC6009845
PMID: 28742462
Abstract
To develop a sensitive scale of iris transillumination suitable for clinical and research use, with the capability of either quantitative analysis or visual matching of images.
Iris transillumination photographic images were used from 70 study subjects with ocular or oculocutaneous albinism. Subjects represented a broad range of ocular pigmentation. A subset of images was subjected to image analysis and ranking by both expert and nonexpert reviewers. Quantitative ordering of images was compared with ordering by visual inspection. Images were binned to establish an 8-point scale. Ranking consistency was evaluated using the Kendall rank correlation coefficient (Kendall's tau). Visual ranking results were assessed using Kendall's coefficient of concordance (Kendall's W) analysis.
There was a high degree of correlation among the image analysis, expert-based and non-expert-based image rankings. Pairwise comparisons of the quantitative ranking with each reviewer generated an average Kendall's tau of 0.83 ± 0.04 (SD). Inter-rater correlation was also high with Kendall's W of 0.96, 0.95, and 0.95 for nonexpert, expert, and all reviewers, respectively.
The current standard for assessing iris transillumination is expert assessment of clinical exam findings. We adapted an image-analysis technique to generate quantitative transillumination values. Quantitative ranking was shown to be highly similar to a ranking produced by both expert and nonexpert reviewers. This finding suggests that the image characteristics used to quantify iris transillumination do not require expert interpretation. Inter-rater rankings were also highly similar, suggesting that varied methods of transillumination ranking are robust in terms of producing reproducible results.
Details
- Title: Subtitle
- A novel iris transillumination grading scale allowing flexible assessment with quantitative image analysis and visual matching
- Creators
- Chen Wang - National Human Genome Research InstituteFlavia Brancusi - a Section on Human Biochemical Genetics , National Human Genome Research Institute, National Institutes of Health , Bethesda , Maryland , USAZaheer M Valivullah - b Undiagnosed Diseases Program, NIH Common Fund, Office of the Director , National Human Genome Research Institute, National Institutes of Health , Bethesda , Maryland , USAMichael G Anderson - d Center for the Prevention and Treatment of Visual Loss , Iowa City Veterans Affairs (VA) Health Care System , Iowa City , Iowa , USADenise Cunningham - e National Eye Institute , National Institutes of Health , Bethesda , Maryland , USAAdam Hedberg-Buenz - d Center for the Prevention and Treatment of Visual Loss , Iowa City Veterans Affairs (VA) Health Care System , Iowa City , Iowa , USABradley Power - a Section on Human Biochemical Genetics , National Human Genome Research Institute, National Institutes of Health , Bethesda , Maryland , USADimitre Simeonov - f Department of Human Biochemical Genetics , University of California, San Francisco , San Francisco , California , USAWilliam A Gahl - a Section on Human Biochemical Genetics , National Human Genome Research Institute, National Institutes of Health , Bethesda , Maryland , USAWadih M Zein - e National Eye Institute , National Institutes of Health , Bethesda , Maryland , USADavid R Adams - a Section on Human Biochemical Genetics , National Human Genome Research Institute, National Institutes of Health , Bethesda , Maryland , USABrian Brooks - e National Eye Institute , National Institutes of Health , Bethesda , Maryland , USA
- Resource Type
- Journal article
- Publication Details
- Ophthalmic genetics, Vol.39(1), pp.41-45
- DOI
- 10.1080/13816810.2017.1342134
- PMID
- 28742462
- PMCID
- PMC6009845
- NLM abbreviation
- Ophthalmic Genet
- ISSN
- 1381-6810
- eISSN
- 1744-5094
- Publisher
- England
- Grant note
- Z99 EY999999 / Intramural NIH HHS R01 EY017673 / NEI NIH HHS
- Language
- English
- Date published
- 01/2018
- Academic Unit
- Molecular Physiology and Biophysics; Ophthalmology and Visual Sciences
- Record Identifier
- 9984025361902771
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