A novel locus for autosomal dominant nonsyndromic hearing loss, DFNA13, maps to chromosome 6p

M R Brown; M S Tomek; L Van Laer; S Smith; J B Kenyon; G Van Camp; R J Smith

doi:10.1086/514892

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A novel locus for autosomal dominant nonsyndromic hearing loss, DFNA13, maps to chromosome 6p

Journal article

Open access

Peer reviewed

A novel locus for autosomal dominant nonsyndromic hearing loss, DFNA13, maps to chromosome 6p

M R Brown, M S Tomek, L Van Laer, S Smith, J B Kenyon, G Van Camp and R J Smith

American journal of human genetics, Vol.61(4), pp.924-927

10/1997

DOI: 10.1086/514892

PMCID: PMC1715982

PMID: 9382104

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Abstract

Nonsyndromic hearing loss (NSHL) is the most common type of hearing impairment in the elderly. Environmental and hereditary factors play an etiologic role, although the relative contribution of each is unknown. To date, 39 NSHL genes have been localized. Twelve produce autosomal dominant hearing loss, most frequently postlingual in onset and progressive in nature. We have ascertained a large, multigenerational family in which a gene for autosomal dominant NSHL is segregating. Affected individuals experience progressive hearing loss beginning in the 2d-4th decades, eventually making the use of amplification mandatory. A novel locus, DFNA13, was identified on chromosome 6p; the disease gene maps to a 4-cM interval flanked by D6S1663 and D6S1691, with a maximum two-point LOD score of 6.409 at D6S299.

United States

Humans

Male

Chromosome Mapping

Hearing Loss, Sensorineural - genetics

Genetic Markers

Chromosomes, Human, Pair 6

Europe - ethnology

Lod Score

Pedigree

Adolescent

Age of Onset

Adult

Female

Aged

Details

Title: Subtitle: A novel locus for autosomal dominant nonsyndromic hearing loss, DFNA13, maps to chromosome 6p
Creators: M R Brown - Molecular Otolaryngology Research Laboratories, Department of Otolaryngology-Head and Neck Surgery, Iowa City, IA 52242, USA
M S Tomek
L Van Laer
S Smith
J B Kenyon
G Van Camp
R J Smith
Resource Type: Journal article
Publication Details: American journal of human genetics, Vol.61(4), pp.924-927
DOI: 10.1086/514892
PMID: 9382104
PMCID: PMC1715982
NLM abbreviation: Am J Hum Genet
ISSN: 0002-9297
eISSN: 1537-6605
Publisher: United States
Language: English
Date published: 10/1997
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
Record Identifier: 9984006308102771

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