Journal article
A novel post-synaptic signal pathway of sympathetic neural regulation of murine colonic motility
The FASEB journal, Vol.34(4), pp.5563-5577
02/21/2020
DOI: 10.1096/fj.201903134R
PMCID: PMC7147814
PMID: 32086857
Abstract
Transcriptome data revealed α1 adrenoceptors (ARs) expression in
platelet-derived growth factor receptor α
+
cells
(PDGFRα
+
cells) in murine colonic musculature. The role of
PDGFRα
+
cells in sympathetic neural regulation of murine
colonic motility was investigated. Norepinephrine, via α1A ARs, activated
a small conductance Ca
2+
-activated K
+
(SK) conductance,
evoked outward currents and hyperpolarized PDGFRα
+
cells (the
α1A AR-SK channel signal pathway). α1 AR agonists increased
intracellular Ca
2+
transients in PDGFRα
+
cells and
inhibited spontaneous phasic contractions of colonic muscle through activation
of a SK conductance. Sympathetic nerve stimulation inhibited both contractions
of distal colon and propulsive contractions represented by the colonic migrating
motor complexes via the α1A AR-SK channel signal pathway. Post-synaptic
signaling through α1A ARs in PDGFRα
+
cells is a novel
mechanism that conveys part of stress responses in the colon.
PDGFRα
+
cells appear to be a primary effector of
sympathetic neural regulation of murine colonic motility.
Details
- Title: Subtitle
- A novel post-synaptic signal pathway of sympathetic neural regulation of murine colonic motility
- Creators
- Masaaki Kurahashi - University of Nevada RenoYoshihiko Kito - Saga UniversitySal Baker - Saga UniversityLibby K. Jennings - University of Nevada RenoJames G. R. Dowers - University of Nevada RenoSang Don Koh - University of Nevada RenoKenton M. Sanders - University of Nevada Reno
- Resource Type
- Journal article
- Publication Details
- The FASEB journal, Vol.34(4), pp.5563-5577
- DOI
- 10.1096/fj.201903134R
- PMID
- 32086857
- PMCID
- PMC7147814
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Grant note
- DOI: 10.13039/100000062, name: HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases, award: R01-DK-091336
- Language
- English
- Date published
- 02/21/2020
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984359777102771
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