Journal article
A novel rat model for the study of postoperative pancreatic fistula
Laboratory animals (London), Vol.56(6), pp.519-527
12/01/2022
DOI: 10.1177/00236772221107347
PMID: 35765854
Abstract
While over the past several decades mortality after pancreatic surgery has decreased to <5%, postoperative morbidity remains remarkably high, ranging from 15% to 65%. The development of a postoperative pancreatic fistula (POPF) is a significant contributor to morbidity in patients undergoing pancreatic surgery. POPF can lead to life-threatening conditions such as intra-abdominal abscess, uncontrolled hemorrhage, sepsis, and death. Rates of POPF have not significantly changed over time, despite the introduction of multiple technical and pharmacologic interventions aimed at their treatment and prevention. Unfortunately, there are few POPF experimental models that have been described in the literature and existing models are unable to reliably reproduce the clinical sequelae of POPF, limiting the development of new methods to prevent and treat POPF. Herein, we describe a new rat experimental model that reliably creates a POPF via transection of the common pancreatic duct.
Details
- Title: Subtitle
- A novel rat model for the study of postoperative pancreatic fistula
- Creators
- Alan F. Utria - University of Iowa Hospitals and ClinicsKevin P. Labadie - University of WashingtonArezou Abbasi - University of WashingtonXianyong Gui - University of WashingtonVenu G. Pillarisetty - University of WashingtonJames O. Park - Seattle UniversityJonathan G. Sham - University of Washington
- Resource Type
- Journal article
- Publication Details
- Laboratory animals (London), Vol.56(6), pp.519-527
- DOI
- 10.1177/00236772221107347
- PMID
- 35765854
- NLM abbreviation
- Lab Anim
- ISSN
- 0023-6772
- eISSN
- 1758-1117
- Publisher
- Sage
- Number of pages
- 9
- Grant note
- Mortenson Construction Beach Family Nowoj Family Americas Hepatopancreatobiliary Association Research Development Award Swim Across America Young Investigator Award
- Language
- English
- Date published
- 12/01/2022
- Academic Unit
- Surgery
- Record Identifier
- 9985015820002771
Metrics
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