A novel role for a nodal-related protein; Xnr3 regulates convergent extension movements via the FGF receptor

Chika Yokota; Matt Kofron; Mike Zuck; Douglas W Houston; Harry Isaacs; Makoto Asashima; Chris C Wylie; Janet Heasman

doi:10.1242/dev.00434

Back

A novel role for a nodal-related protein; Xnr3 regulates convergent extension movements via the FGF receptor

Journal article

Open access

Peer reviewed

A novel role for a nodal-related protein; Xnr3 regulates convergent extension movements via the FGF receptor

Chika Yokota, Matt Kofron, Mike Zuck, Douglas W Houston, Harry Isaacs, Makoto Asashima, Chris C Wylie and Janet Heasman

Development (Cambridge), Vol.130(10), pp.2199-2212

05/2003

DOI: 10.1242/dev.00434

PMID: 12668633

Files and links (1)

url

https://doi.org/10.1242/dev.00434View

Published (Version of record) Open Access

Abstract

Convergent extension behaviour is critical for the formation of the vertebrate body axis. In Xenopus, components of the Wnt signaling pathway have been shown to be required for convergent extension movements but the relationship between cell fate and morphogenesis is little understood. We show by loss of function analysis that Xnr3 activates Xbra expression through FGFR1. We show that eFGF activity is not essential in the pathway, and that dishevelled acts downstream of Xnr3 and not in a parallel pathway. We provide evidence for the involvement of the EGF-CFC protein FRL1, and suggest that the pro-domain of Xnr3 may be required for its activity. Since Xnr3 is a direct target of the maternal betacatenin/XTcf3 signaling pathway, it provides the link between the initial, maternally controlled, allocation of cell fate, and the morphogenetic movements of cells derived from the organizer.

Organizers, Embryonic - physiology

Receptor, Fibroblast Growth Factor, Type 1

Xenopus Proteins - genetics

Oligonucleotides, Antisense - metabolism

Cell Movement - physiology

Gene Expression Regulation, Developmental

Receptors, Fibroblast Growth Factor - genetics

Xenopus laevis - embryology

Intercellular Signaling Peptides and Proteins

Glycoproteins

Receptor Protein-Tyrosine Kinases - metabolism

T-Box Domain Proteins - genetics

T-Box Domain Proteins - metabolism

Body Patterning - physiology

Phenotype

Animals

Oocytes - physiology

Proteins - metabolism

Transforming Growth Factor beta - genetics

Receptor Protein-Tyrosine Kinases - genetics

Receptors, Fibroblast Growth Factor - metabolism

Biomarkers

Signal Transduction - physiology

Xenopus Proteins - metabolism

Xenopus laevis - physiology

Transforming Growth Factor beta - metabolism

Details

Title: Subtitle: A novel role for a nodal-related protein; Xnr3 regulates convergent extension movements via the FGF receptor
Creators: Chika Yokota - Division of Developmental Biology, Cincinnati Children's Research Foundation, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA
Matt Kofron
Mike Zuck
Douglas W Houston
Harry Isaacs
Makoto Asashima
Chris C Wylie
Janet Heasman
Resource Type: Journal article
Publication Details: Development (Cambridge), Vol.130(10), pp.2199-2212
Publisher: England
DOI: 10.1242/dev.00434
PMID: 12668633
ISSN: 0950-1991
eISSN: 1477-9129
Grant note: R01 HD33002 / NICHD NIH HHS
Language: English
Date published: 05/2003
Academic Unit: Biology
Record Identifier: 9983992077702771

Metrics

34 Record Views

80 Times Cited - Web of Science

See more details