Journal article
A novel role of Shc adaptor proteins in steroid hormone-regulated cancers
Endocrine-related cancer, Vol.16(1), pp.1-16
03/01/2009
DOI: 10.1677/ERC-08-0179
PMCID: PMC2776657
PMID: 19001530
Abstract
Tyrosine phosphorylation plays a critical role in growth regulation, and its aberrant regulation can be involved in carcinogenesis. The association of Shc (Src homolog and collagen homolog) adaptor protein family members in tyrosine phosphorylation signaling pathway is well recognized. Shc adaptor proteins transmit activated tyrosine phosphorylation signaling that suggest their plausible role in growth regulation including carcinogenesis and metastasis. In parallel, by sharing a similar mechanism of carcinogenesis, the steroids are involved in the early stage of carcinogenesis as well as the regulation of cancer progression and metastatic processes. Recent evidence indicates a cross-talk between tyrosine phosphorylation signaling and steroid hormone action in epithelial cells, including prostate and breast cancer cells. Therefore, the members of Shc proteins may function as mediators between tyrosine phosphorylation and steroid signaling in steroid-regulated cell proliferation and carcinogenesis. In this communication, we discuss the novel roles of Shc proteins, specifically p52(Shc) and p66(Shc), in steroid hormone-regulated cancers and a novel molecular mechanism by which redox signaling induced by p66(Shc) mediates steroid action via a non-genomic pathway. The p66(Shc) protein may serve as an effective biomarker for predicting cancer prognosis as well as a useful target for treatment.
Details
- Title: Subtitle
- A novel role of Shc adaptor proteins in steroid hormone-regulated cancers
- Creators
- Syed Mahfuzul Alam - University of Nebraska Medical CenterMythilypriya Rajendran - University of Nebraska Medical CenterShouqiang Ouyang - University of Nebraska Medical CenterSuresh Veeramani - University of Nebraska Medical CenterLi Zhang - University of Nebraska Medical CenterMing-Fong Lin - University of Nebraska Medical Center
- Resource Type
- Journal article
- Publication Details
- Endocrine-related cancer, Vol.16(1), pp.1-16
- Publisher
- Bioscientifica Ltd
- DOI
- 10.1677/ERC-08-0179
- PMID
- 19001530
- PMCID
- PMC2776657
- ISSN
- 1351-0088
- eISSN
- 1479-6821
- Number of pages
- 16
- Grant note
- W81XWH-06-1-0070; W81XWH-08-1-0459 / Department of Defense; United States Department of Defense Nebraska Research Initiative for Cancer Glycobiology R01 CA88184 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01CA088184 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) National Cancer Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) LB 506 / Nebraska Cancer and Smoking Disease Research Program
- Language
- English
- Date published
- 03/01/2009
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359884802771
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