Journal article
A novel t(3;8)(q27;q24.1) simultaneously involving both the BCL6 and MYC genes in a diffuse large B-cell lymphoma
Cancer genetics and cytogenetics, Vol.172(1), pp.45-53
01/01/2007
DOI: 10.1016/j.cancergencyto.2006.07.016
PMID: 17175379
Abstract
Diffuse large B-cell lymphomas (DLBCLs) are a clinically and biologically heterogeneous group of hematologic malignancies. Specific genetic aberrations underlie some of this heterogeneity. These genetic events include distinct and separate translocations resulting in the dysregulated expression of either BCL6 protein with the t(3;14)(q27;q32) or c-MYC protein with the t(8;14)(q24;q32), as a consequence of the juxtaposition of these oncogenes with heterologous promoters or enhancers, such as those of the immunoglobulin heavy chain gene. Here, we report the case of a patient with DLBCL with a unique t(3;8)(q27;q24.1) that involves the BCL6 and MYC genes. We know of no previous report of this translocation in DLBCL, which simultaneously affects two key genes implicated in lymphomagenesis and may reflect a novel genetic mechanism in neoplastic transformation.
Details
- Title: Subtitle
- A novel t(3;8)(q27;q24.1) simultaneously involving both the BCL6 and MYC genes in a diffuse large B-cell lymphoma
- Creators
- Huan-You Wang - Department of Pathology and Laboratory Medicine, School of Medicine, Hospital of the University of Pennsylvania, 7.103 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19014-4284, USAAaron D BosslerAndras SchafferEwa TomczakDoris DiPatriDale M FrankPeter C NowellAdam Bagg
- Resource Type
- Journal article
- Publication Details
- Cancer genetics and cytogenetics, Vol.172(1), pp.45-53
- Publisher
- United States
- DOI
- 10.1016/j.cancergencyto.2006.07.016
- PMID
- 17175379
- ISSN
- 0165-4608
- eISSN
- 1873-4456
- Language
- English
- Date published
- 01/01/2007
- Academic Unit
- Pathology
- Record Identifier
- 9984047983602771
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