A novel varicella-zoster virus gE mutation discovered in two Swedish isolates

Benita Zweygberg Wirgart; Victor Estrada; Wallen Jackson; Annika Linde; Charles Grose

doi:10.1016/j.jcv.2006.06.007

Back

A novel varicella-zoster virus gE mutation discovered in two Swedish isolates

Journal article

Peer reviewed

A novel varicella-zoster virus gE mutation discovered in two Swedish isolates

Benita Zweygberg Wirgart, Victor Estrada, Wallen Jackson, Annika Linde and Charles Grose

Journal of clinical virology, Vol.37(2), pp.134-136

2006

DOI: 10.1016/j.jcv.2006.06.007

PMID: 16905355

View Online

Abstract

Two VZV glycoprotein E (gE D150N) mutant strains were collected in North America in 1995 and in 1999. We now report a novel VZV gE mutant virus discovered in Europe in two VZV strains collected in Stockholm, Sweden, in 1990 and 1999. To characterize the two isolates identified among a total of 634 VZV isolates collected over a 15-year period at the Karolinska University Hospital. VZV genes were amplified by polymerase chain reaction and their sequences were compared to the genomic sequence of VZV-Dumas prototype strain. A mutation within the gE gene in an epitope recognized by the 3B3 monoclonal antibody was identified in both isolates. A different residue was changed (R152S) compared to the North American strains (D150N). The occurrence of a VZV gE mutant virus is unusual, but probably a recurring event in Europe and North America. It is unknown whether widespread varicella vaccination programs will alter the rate at which these mutant viruses are isolated.

Varicella-zoster

VZV

Mutation

Sequencing

Virus isolation

Glycoprotein E

Details

Title: Subtitle: A novel varicella-zoster virus gE mutation discovered in two Swedish isolates
Creators: Benita Zweygberg Wirgart - Department of Clinical Microbiology, Karolinska University Hospital, L2:02, SE-171 76 Stockholm, Sweden
Victor Estrada - Department of Virology Division, University of Iowa, Iowa City, IA 52242, USA
Wallen Jackson - Department of Virology Division, University of Iowa, Iowa City, IA 52242, USA
Annika Linde - Department of Epidemiology, The Swedish Institute for Infectious Disease Control, SE-171 82 Solna, Sweden
Charles Grose - Department of Virology Division, University of Iowa, Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: Journal of clinical virology, Vol.37(2), pp.134-136
DOI: 10.1016/j.jcv.2006.06.007
PMID: 16905355
NLM abbreviation: J Clin Virol
ISSN: 1386-6532
eISSN: 1873-5967
Publisher: Elsevier B.V
Language: English
Date published: 2006
Academic Unit: Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
Record Identifier: 9984093349402771

Metrics

26 Record Views

14 Times Cited - Web of Science