Journal article
A nuclear polymorphism at the 8q24 region is associated with improved survival time and chemo-response in high-grade serous ovarian cancer
Oncology letters, Vol.22(4), pp.1-733
10/01/2021
DOI: 10.3892/ol.2021.12994
PMCID: PMC8371958
PMID: 34429773
Abstract
The 8q24 chromosomal region is strongly associated with an increased risk of ovarian cancer. One single nucleotide polymorphism that is associated with ovarian cancer in this region is rs6983267, located within the long non-coding RNA colon cancer associated transcript 2 (CCAT2). The aim of the present study was to assess the association between rs6983267 and clinical outcomes in patients with high-grade serous ovarian cancer (HGSOC). The present retrospective genetic association study utilized Sanger sequencing to determine the genotype at the rs6983267 locus (GG, GT, TT) in 98 patients with HGSOC. Survival time and chemotherapy responses between patients were compared with the TT genotype and patients with a genotype containing a G allele (GT, GG). Survival analyses were performed using Cox proportional hazard ratio analysis. Association with chemo-response was performed using a logistic regression. The results revealed that patients with HGSOC and the TT genotype at the rs6983267 locus had improved survival time compared with patients with genotypes containing a G allele [hazard ratio=0.59; 95% confidence interval (CI), 0.36-0.97; P=0.039] and were significantly associated with International Federation of Gynecology and Obstetrics stage [odds ratio (OR)=5.34; 95% CI, 1.50-22.62; P=0.014] and positive chemo-response (OR=4.51; 95% CI, 1.40-18.00; P=0.018). In summary, patients with HGSOC and the TT genotype at the rs6983267 locus had improved survival time compared with those with a G allele, despite being associated with more advanced disease; this was possibly due to an improved response to chemotherapy.
Details
- Title: Subtitle
- A nuclear polymorphism at the 8q24 region is associated with improved survival time and chemo-response in high-grade serous ovarian cancer
- Creators
- Danielle Ikoma - University of Iowa Hospitals and ClinicsNicholas Cardillo - University of Iowa Hospitals and ClinicsEric Devor - University of IowaJesus Gonzalez-Bosquet - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Oncology letters, Vol.22(4), pp.1-733
- DOI
- 10.3892/ol.2021.12994
- PMID
- 34429773
- PMCID
- PMC8371958
- NLM abbreviation
- Oncol Lett
- ISSN
- 1792-1074
- eISSN
- 1792-1082
- Publisher
- Spandidos Publ Ltd
- Number of pages
- 9
- Grant note
- R01 CA99908; R01 CA184101 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA American Association of Obstetricians and Gynecologists Foundation Bridge Funding Award Basic Research Fund from the Department of Obstetrics and Gynecology at the University of Iowa
- Language
- English
- Date published
- 10/01/2021
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9984315573302771
Metrics
18 Record Views