Journal article
A one-flask synthesis of α,α-bisphosphonates via enolate chemistry
Tetrahedron letters, Vol.43(48), pp.8665-8668
2002
DOI: 10.1016/S0040-4039(02)02148-2
Abstract
Treatment of several carbonyl compounds with excess strong base and diethyl phosphorochloridite results in formation of two carbonphosphorus bonds at the α carbon. Oxidation of the immediate product with H 2O 2 affords the corresponding α,α-bisphosphonate in moderate to very good yields. Treatment of several carbonyl compounds with excess base and diethyl phosphorochloridite resulted in formation of two CP bonds, and oxidation of the initial product with H 2O 2 affords an α,α-bisphosphonate in a one-flask protocol.
Details
- Title: Subtitle
- A one-flask synthesis of α,α-bisphosphonates via enolate chemistry
- Creators
- Yanming Du - Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USAKang-Yeoun Jung - Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USADavid F Wiemer - Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USA
- Resource Type
- Journal article
- Publication Details
- Tetrahedron letters, Vol.43(48), pp.8665-8668
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/S0040-4039(02)02148-2
- ISSN
- 0040-4039
- eISSN
- 1873-3581
- Language
- English
- Date published
- 2002
- Academic Unit
- Chemistry; Neuroscience and Pharmacology
- Record Identifier
- 9983985933702771
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