Journal article
A patient with simultaneous absence of “classical” natural killer cells (CD3 −, CD16 +, and NKH1 +) and expansion of CD3 +, CD4 −, CD8 −, NKH1 + subset
Journal of allergy and clinical immunology, Vol.85(2), pp.453-459
1990
DOI: 10.1016/0091-6749(90)90155-W
PMID: 2303649
Abstract
The clinical manifestations of putative natural killer (NK) cell deficiency are not well-known but theoretically should include recurrent tumors and systemic viral infections. In this article, we discuss a patient with recurrent candylomata, vulvar and cervical carcinoma in situ, pulmonary infiltrates of unknown significance, and a hypercoagulable state. This patient has a dramatic persistent deficiency in her circulating “classic” NK cells (CD3
−, CD16
+, NKH1
+) and a simultaneous persistent expansion of a normally minor lymphocyte cell subset (CD3
+, CD4
−, CD8
−, NKH1
+) that does not express the αβ heterodimer of the T cell receptor. T-lymphocyte function, as measured by mitogen and alloantigen responsiveness in vitro, was normal. The coexistence of this particular clinical complex with this unusual set of laboratory abnormalities tends to emphasize our meager understanding of the biologic role of NK cells. At the very least, these findings suggest that the clinical manifestations of NK cell deficiency need not be dominated by disseminated systemic viral infections and that perhaps there should be a higher index of suspicion for the scrutinization of NK cell function.
Details
- Title: Subtitle
- A patient with simultaneous absence of “classical” natural killer cells (CD3 −, CD16 +, and NKH1 +) and expansion of CD3 +, CD4 −, CD8 −, NKH1 + subset
- Creators
- Zuhair K BallasJames M TurnerDeborah A TurnerElizabeth A GoetzmanJohn D Kemp
- Resource Type
- Journal article
- Publication Details
- Journal of allergy and clinical immunology, Vol.85(2), pp.453-459
- Publisher
- Mosby, Inc
- DOI
- 10.1016/0091-6749(90)90155-W
- PMID
- 2303649
- ISSN
- 0091-6749
- eISSN
- 1097-6825
- Language
- English
- Date published
- 1990
- Academic Unit
- Pathology; Immunology; Internal Medicine
- Record Identifier
- 9984094764102771
Metrics
20 Record Views