Journal article
A pediatric case series of acute hemolysis after administration of intravenous immunoglobulin
American journal of hematology, Vol.84(11), pp.771-772
2009
DOI: 10.1002/ajh.21544
PMID: 19806664
Abstract
Intravenous immunoglobulin (IVIG) is commonly used as an immunemodulatory treatment for patients with autoimmune and inflammatory diseases [1]. Antibody-mediated hemolysis of red blood cells (RBCs) after IVIG infusion is a recognized but rare side effect [2]. This retrospective case series describes four pediatric patients at a single institution who developed significant hemolytic reactions after treatment with IVIG for either Kawasaki disease or acute inflammatory demyelinating polyradiculoneuropathy. Patients ranged in age from 5 months to 14 years. The mean decrease in hemoglobin level after IVIG was 5.1 ± 0.36 g/dL (mean ± SD). Three of the four patients required RBC transfusion, and all the patients recovered spontaneously within 1 month of IVIG infusion. This case series illustrates a relatively uncommon, but potentially severe side effect of IVIG treatment, and demonstrates the importance of monitoring hemoglobin levels after IVIG therapy.
Details
- Title: Subtitle
- A pediatric case series of acute hemolysis after administration of intravenous immunoglobulin
- Creators
- David J GORDON - Division of Hematology-Oncology, Department of Medicine, Children's Hospital Boston, Boston, Massachusetts, United StatesSteven R SLOAN - Department of Laboratory Medicine, Children's Hospital Boston, Boston, Massachusetts, United StatesJill L. O DE JONG - Division of Hematology-Oncology, Department of Medicine, Children's Hospital Boston, Boston, Massachusetts, United States
- Resource Type
- Journal article
- Publication Details
- American journal of hematology, Vol.84(11), pp.771-772
- Publisher
- Wiley-Liss
- DOI
- 10.1002/ajh.21544
- PMID
- 19806664
- ISSN
- 0361-8609
- eISSN
- 1096-8652
- Language
- English
- Date published
- 2009
- Academic Unit
- Stead Family Department of Pediatrics; Hematology/Oncology
- Record Identifier
- 9984093469202771
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