Logo image
Back
A phase I-II evaluation of veliparib (NSC #737664), topotecan, and filgrastim or pegfilgrastim in the treatment of persistent or recurrent carcinoma of the uterine cervix: an NRG Oncology/Gynecologic Oncology Group study
Journal article   Peer reviewed

A phase I-II evaluation of veliparib (NSC #737664), topotecan, and filgrastim or pegfilgrastim in the treatment of persistent or recurrent carcinoma of the uterine cervix: an NRG Oncology/Gynecologic Oncology Group study

Charles Kunos, Wei Deng, Dawn Dawson, Jayanthi S Lea, Kristine M Zanotti, Heidi J Gray, David P Bender, Perry P Guaglianone, Jori S Carter and Kathleen N Moore
International journal of gynecological cancer, Vol.25(3), pp.484-492
03/2015
DOI: 10.1097/IGC.0000000000000380
PMCID: PMC4336206
PMID: 25594147
url
http://doi.org/10.1097/IGC.0000000000000380View
Open Access

Abstract

The aim of this study was to evaluate the tolerability and efficacy of poly(ADP-ribose) polymerase (PARP) inhibition by veliparib during cytotoxic topotecan administration with filgrastim or pegfilgrastim neutrophil support in women with persistent or recurrent uterine cervix cancer. This phase I-II trial examined twice-daily oral veliparib (10 mg) given during once-daily intravenous topotecan (0.6 mg/m²) on days 1 to 5 of each treatment cycle. Cycles were repeated every 21 days until disease progression or until toxicity prohibited further therapy. Toxicity and objective response rate were primary endpoints. Twenty-seven women were enrolled. Frequently reported grade 3 or higher treatment-related toxicities were anemia (59%), thrombocytopenia (44%), leukopenia (22%), and neutropenia (19%). There were 2 partial responses (7% [90% confidence interval, 1%-22%]). Four patients had a disease progression date more than 6 months after the start of veliparib-topotecan therapy. Patients with low immunohistochemical expression (0-1+) of PARP-1 in their primary uterine cervix cancer were more likely to have a longer progression-free interval (hazard ratio, 0.25; P = 0.02) and survival (hazard ratio, 0.12; P = 0.005) after veliparib-topotecan therapy. Clinical activity of a veliparib-topotecan combination was minimal in women with persistent or recurrent uterine cervix cancer. Women whose uterine cervix cancers express PARP-1 at low levels may benefit preferentially from PARP inhibitors combined with cytotoxic therapies, suggesting further study of PARP expression as an integral triage biomarker.
 Recombinant Proteins - therapeutic use Cell Cycle Proteins - analysis Humans Middle Aged Antineoplastic Combined Chemotherapy Protocols - adverse effects Neoplasm Recurrence, Local - drug therapy Carcinoma - chemistry Ribonucleotide Reductases - analysis Benzimidazoles - administration & dosage Adult Female Filgrastim - therapeutic use Benzimidazoles - adverse effects Neutropenia - chemically induced Carcinoma - drug therapy Polyethylene Glycols Anemia - chemically induced Poly(ADP-ribose) Polymerases - analysis Topotecan - adverse effects Uterine Cervical Neoplasms - drug therapy Thrombocytopenia - chemically induced Granulocyte Colony-Stimulating Factor - therapeutic use Neoplasm Recurrence, Local - chemistry Disease Progression Neutropenia - prevention & control Topotecan - administration & dosage Aged Uterine Cervical Neoplasms - chemistry Poly (ADP-Ribose) Polymerase-1

Details

Metrics

41 Record Views
54 Times Cited - Web of Science
Logo image