Journal article
A phase II evaluation of lapatinib in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: A gynecologic oncology group study
Gynecologic Oncology, Vol.124(3), pp.569-574
2012
DOI: 10.1016/j.ygyno.2011.10.022
PMCID: PMC3971755
PMID: 22037316
Abstract
Activation and dimerization of the ERBB family play a role in the pathogenesis and progression of ovarian cancer. We conducted a phase II trial to evaluate the activity and tolerability of lapatinib in patients with recurrent or persistent epithelial ovarian cancer (EOC) and to explore the clinical value of expression levels of epidermal growth factor receptors (EGFR), phosphorylated EGFR, HER-2/neu, and Ki-67, and the presence of EGFR mutations. Eligible patients had recurrent or persistent EOC or primary peritoneal carcinoma, measurable disease, and up to 2 prior chemotherapy regimens for recurrent disease. Patients were treated with lapatinib 1500 mg/day. The primary endpoint of efficacy was 6-month progression free survival (PFS). Twenty-five of 28 patients were eligible and evaluable for analysis of efficacy and toxicity. Two (8.0%) were alive and progression-free at 6 months. No objective responses were observed. There were 1 grade 4 toxicity (fatigue) and few grade 3 toxicities. Associations between Ki-67 with prior platinum-free interval, PFS, and a polymorphism in EGFR were suggested. Lapatinib has minimal activity in recurrent ovarian cancer. Ki-67 expression may be associated with prior PFS and a polymorphism in EGFR exon 20 (2361G>A, Q787Q). ► Lapatinib has minimal activity in unselected recurrent ovarian cancer. ► Ki-67 expression may be associated with prior PFS and a polymorphism in EGFR exon 20. ► EGFR and HER2/neu are overexpressed in a minority of ovarian cancers.
Details
- Title: Subtitle
- A phase II evaluation of lapatinib in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: A gynecologic oncology group study
- Creators
- Agustin A GarciaMichael W SillHeather A LankesAndrew K GodwinRobert S MannelDeborah K ArmstrongRobert L CarollaMarcia K LiepmanNick M SpirtosEdgar G FischerKimberly K Leslie - University of Iowa, Obstetrics and Gynecology
- Resource Type
- Journal article
- Publication Details
- Gynecologic Oncology, Vol.124(3), pp.569-574
- DOI
- 10.1016/j.ygyno.2011.10.022
- PMID
- 22037316
- PMCID
- PMC3971755
- NLM abbreviation
- Gynecol Oncol
- ISSN
- 0090-8258
- eISSN
- 1095-6859
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2012
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9983557770802771
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