A phase I/II trial of intravenous L-2-oxothiazolidine-4-carboxylic acid (procysteine) in asymptomatic HIV-infected subjects

R. C KALAYJIAN; Gail Skowron; K. O STORY; W. B ROWE; K THOMPSON; Dennis Goldberg; S TRIMBO; Michael M Lederman; R.-T EMGUSHOV; Michael Chance; S. A SPELL; P. R BORUM; L. S WEBB; Kenneth H Mayer; J. B JACKSON; Belinda Yen-Lieberman

A phase I/II trial of intravenous L-2-oxothiazolidine-4-carboxylic acid (procysteine) in asymptomatic HIV-infected subjects

Journal article

Peer reviewed

A phase I/II trial of intravenous L-2-oxothiazolidine-4-carboxylic acid (procysteine) in asymptomatic HIV-infected subjects

R. C KALAYJIAN, Gail Skowron, K. O STORY, W. B ROWE, K THOMPSON, Dennis Goldberg, S TRIMBO, Michael M Lederman, R.-T EMGUSHOV, Michael Chance, …

Journal of acquired immune deficiency syndromes (1988), Vol.7(4), pp.369-374

1994

PMID: 7907662

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Abstract

Twenty-four asymptomatic, HIV-1-seropositive subjects with CD4 cell counts of > or = 400/microliters participated in a Phase I/II, dose escalation trial of intravenous L-2-oxothiazolidine-4-carboxylic acid (OTC: Procysteine). Four groups of six subjects each were consecutively assigned to receive OTC at an initial dose of 3, 10, 30, or 100 mg/kg, followed by the same dose given twice weekly for 6 weeks. Increases in whole-blood glutathione were observed in the highest dosage group after 6 weeks of therapy. No effects on changes in CD4 cell counts, viral load, or proviral DNA frequency were observed among the four dosage groups, although a decline in beta 2-microglobulin levels was apparent in the highest dosage group. One subject withdrew due to headaches; other probable adverse events including rash, flushing, pruritus, lightheadedness, and diminished concentration were self-limited.

Antiviral agents

Biological and medical sciences

Medical sciences

Pharmacology. Drug treatments

Antibiotics. Antiinfectious agents. Antiparasitic agents

Details

Title: Subtitle: A phase I/II trial of intravenous L-2-oxothiazolidine-4-carboxylic acid (procysteine) in asymptomatic HIV-infected subjects
Creators: R. C KALAYJIAN - Univ. hosp. Cleveland, Case Western Reserve univ. school medicine, dep. medicine pathology, Cleveland OH, United States
Gail Skowron - Univ. hosp. Cleveland, Case Western Reserve univ. school medicine, dep. medicine pathology, Cleveland OH, United States
K. O STORY - Univ. hosp. Cleveland, Case Western Reserve univ. school medicine, dep. medicine pathology, Cleveland OH, United States
W. B ROWE - Univ. hosp. Cleveland, Case Western Reserve univ. school medicine, dep. medicine pathology, Cleveland OH, United States
K THOMPSON - Univ. hosp. Cleveland, Case Western Reserve univ. school medicine, dep. medicine pathology, Cleveland OH, United States
Dennis Goldberg
S TRIMBO - Univ. hosp. Cleveland, Case Western Reserve univ. school medicine, dep. medicine pathology, Cleveland OH, United States
Michael M Lederman - Univ. hosp. Cleveland, Case Western Reserve univ. school medicine, dep. medicine pathology, Cleveland OH, United States
R.-T EMGUSHOV - Univ. hosp. Cleveland, Case Western Reserve univ. school medicine, dep. medicine pathology, Cleveland OH, United States
Michael Chance - Univ. hosp. Cleveland, Case Western Reserve univ. school medicine, dep. medicine pathology, Cleveland OH, United States
S. A SPELL - Univ. hosp. Cleveland, Case Western Reserve univ. school medicine, dep. medicine pathology, Cleveland OH, United States
P. R BORUM - Univ. hosp. Cleveland, Case Western Reserve univ. school medicine, dep. medicine pathology, Cleveland OH, United States
L. S WEBB - Univ. hosp. Cleveland, Case Western Reserve univ. school medicine, dep. medicine pathology, Cleveland OH, United States
Kenneth H Mayer - Univ. hosp. Cleveland, Case Western Reserve univ. school medicine, dep. medicine pathology, Cleveland OH, United States
J. B JACKSON - Univ. hosp. Cleveland, Case Western Reserve univ. school medicine, dep. medicine pathology, Cleveland OH, United States
Belinda Yen-Lieberman - Univ. hosp. Cleveland, Case Western Reserve univ. school medicine, dep. medicine pathology, Cleveland OH, United States
Resource Type: Journal article
Publication Details: Journal of acquired immune deficiency syndromes (1988), Vol.7(4), pp.369-374
Publisher: Raven Press; New York, NY
PMID: 7907662
ISSN: 0894-9255
eISSN: 2331-2289
Language: English
Date published: 1994
Academic Unit: Pathology; VPMA - Administration
Record Identifier: 9984047991302771

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