Journal article
A physiologically active polysaccharide hydrogel promotes wound healing
Journal of biomedical materials research. Part A, Vol.94A(1), pp.193-204
07/01/2010
DOI: 10.1002/jbm.a.32711
PMID: 20128009
Abstract
When the skin is injured, the subcutaneous tissues and organs are threatened by pathogens and excessive water loss. Wound dressings are, therefore, needed to protect the wound site from infection and improve the wound closure. Natural polysaccharides have been applied for various biomaterials including wound dressings, which show their advantages in biocompatibility, low toxicity, and pharmaceutical biomedical activity. In this study, a natural polysaccharide Bletilla striata polysaccharide (BSP) hydrogel is prepared by an oxidation and crosslinking methods. This BSP hydrogel represents preferable swelling ability and appropriate water vapor transmission rate. Using a full-thickness trauma mouse model, the hydrogel is applied on the in vim cutaneous wound healing. Compared with the control groups, the BSP hydrogel achieves the much better healing results. The quantification of the infiltrating inflammatory cells and the level of tumor necrosis factor alpha (TNF-alpha) in the BSP group are attenuated, whereas the secretion of the epidermal growth factor (EGF) is highly elevated. On the 11th day after surgery, the wound area in the BSP hydrogel group is only 1/5-1/3 of those in the control groups. This new BSP hydrogel is proved to control the inflammatory responses and accelerate the wound closure and has potential application in wound healing. (c) 2010 Wiley Periodicals, Inc. J Biomed Mater Res 94A: 193-204, 2010
Details
- Title: Subtitle
- A physiologically active polysaccharide hydrogel promotes wound healing
- Creators
- Yi Luo - Nanjing UniversityHuajia Diao - Nanjing UniversitySuhua Xia - Nanjing UniversityLei Dong - Nanjing UniversityJiangning Chen - Nanjing UniversityJunfeng Zhang - Nanjing University
- Resource Type
- Journal article
- Publication Details
- Journal of biomedical materials research. Part A, Vol.94A(1), pp.193-204
- Publisher
- Wiley
- DOI
- 10.1002/jbm.a.32711
- PMID
- 20128009
- ISSN
- 1549-3296
- eISSN
- 1552-4965
- Number of pages
- 12
- Grant note
- 50673041; 30771036 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) 2006CB503909; 2004CB518603 / National Basic Research Foundation of China; National Basic Research Program of China 2009ZX09503-028 / National Pharmaceutical Program Chinese Ministry of Education; Ministry of Education, China
- Language
- English
- Date published
- 07/01/2010
- Academic Unit
- Urology
- Record Identifier
- 9984320073902771
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