Journal article
A pilot investigation of the impact of smoking cessation on biological age
The American journal on addictions, Vol.26(2), pp.129-135
03/2017
DOI: 10.1111/ajad.12502
PMCID: PMC5323361
PMID: 28106943
Abstract
Smoking is known to increase biological age. However, whether this process is reversible through smoking cessation is not known. In this pilot study, we attempt to determine whether smoking cessation reduces biological age.
We conducted regression analyses of methylation data from 22 subjects, as they entered and exited inpatient substance use treatment, to determine change in biological age, as indicated by the deviation of their methylomic age from chronological age across two time points.
We found that, as compared to those subjects who did not stop smoking, subjects who significantly decreased their smoking consumption over a 1 month time period exhibited a marked reduction in methylomic age.
The rapid and substantial reversal of accelerated aging associated with successful smoking cessation suggests that it can reverse well-known smoking effects on methylomic aging. This preliminary finding can be readily examined in other, larger data sets, and if replicated, this observation may provide smokers with yet another good reason to quit smoking.
Successful smoking cessation makes patients appear biologically younger than they were at baseline, and to do so quite rapidly. In today's youth driven society, our observations may serve as a powerful impetus for some to quit smoking. (Am J Addict 2017;26:129-135).
Details
- Title: Subtitle
- A pilot investigation of the impact of smoking cessation on biological age
- Creators
- Man-Kit Lei - Department of Sociology, University of Georgia, Athens, GeorgiaSteven R H Beach - Department of Psychology, University of Georgia, Athens, GeorgiaMeeshanthini V Dogan - Department of Psychiatry, University of Iowa, Iowa City, IowaRobert A Philibert - Behavioral Diagnostics, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- The American journal on addictions, Vol.26(2), pp.129-135
- DOI
- 10.1111/ajad.12502
- PMID
- 28106943
- PMCID
- PMC5323361
- NLM abbreviation
- Am J Addict
- ISSN
- 1055-0496
- eISSN
- 1521-0391
- Publisher
- England
- Grant note
- R01 DA037648 / NIDA NIH HHS R44 AA022041 / NIAAA NIH HHS
- Language
- English
- Date published
- 03/2017
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984004098402771
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