Journal article
A pilot prospective randomized trial of postoperative epoetin alfa in patients undergoing major operation for upper gastrointestinal malignancy
American journal of clinical oncology, Vol.32(6), pp.570-573
12/01/2009
DOI: 10.1097/COC.0b013e31819790a8
PMID: 19675446
Abstract
INTRODUCTIONStrategies to reduce red blood transfusion utilization in cancer patients undergoing operation are needed.HYPOTHESISPostoperative epoetin alfa (40,000 units subcutaneous on postoperative days 1 and 7) is associated with improved hematologic parameters in patients undergoing major abdominal surgery for malignancy.MATERIALS AND METHODSProspective, blinded, randomized trial of epoetin alfa (40,000 units subcutaneous on postoperative days 1 and 7) versus placebo in patients undergoing major abdominal operation for malignancy. Primary endpoints were immature reticulocyte fraction, reticulocyte count, and hemoglobin, which were measured on postoperative days 4, 7, and between 14 and 20. Secondary endpoints were transfusions and complications in the 2 groups.RESULTSForty patients were enrolled. There were no significant differences in immature reticulocyte fraction (P = 0.78), reticulocyte count (P = 0.42), or hemoglobin (0.35) in patients randomized to receive epoetin alfa versus placebo. There was no significant difference in red blood cell transfusion rate or postoperative complications in patients who received epoetin alfa compared with placebo.DISCUSSIONThe use of postoperative epoetin alfa (40,000 units subcutaneous on postoperative days 1 and 7) in patients undergoing major operation for abdominal or pelvic malignancy is not supported by this randomized trial.
Details
- Title: Subtitle
- A pilot prospective randomized trial of postoperative epoetin alfa in patients undergoing major operation for upper gastrointestinal malignancy
- Creators
- Stephen R Grobmyer - University of FloridaAlan W Hemming - University of Florida Health Science CenterNeil Harris - University of Florida HealthKevin Behrns - University of Florida HealthHenrietta Logan - University of Florida Health Science CenterRobin D Kim - University of Florida Health Science CenterMyron Chang - University of Florida HealthWilliam G Cance - University of Florida HealthSteven N Hochwald - University of Florida Health Science Center
- Resource Type
- Journal article
- Publication Details
- American journal of clinical oncology, Vol.32(6), pp.570-573
- DOI
- 10.1097/COC.0b013e31819790a8
- PMID
- 19675446
- ISSN
- 0277-3732
- eISSN
- 1537-453X
- Language
- English
- Date published
- 12/01/2009
- Academic Unit
- Preventive and Community Dentistry; Surgery
- Record Identifier
- 9984322808002771
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