Journal article
A plasma protein-based risk score to predict hip fractures
Nature aging, Vol.4(8), pp.1064-1075
08/2024
DOI: 10.1038/s43587-024-00639-7
PMCID: PMC11333168
PMID: 38802582
Abstract
As there are effective treatments to reduce hip fractures, identification of patients at high risk of hip fracture is important to inform efficient intervention strategies. To obtain a new tool for hip fracture prediction, we developed a protein-based risk score in the Cardiovascular Health Study using an aptamer-based proteomic platform. The proteomic risk score predicted incident hip fractures and improved hip fracture discrimination in two Trøndelag Health Study validation cohorts using the same aptamer-based platform. When transferred to an antibody-based proteomic platform in a UK Biobank validation cohort, the proteomic risk score was strongly associated with hip fractures (hazard ratio per s.d. increase, 1.64; 95% confidence interval 1.53-1.77). The proteomic risk score, but not available polygenic risk scores for fractures or bone mineral density, improved the C-index beyond the fracture risk assessment tool (FRAX), which integrates information from clinical risk factors (C-index, FRAX 0.735 versus FRAX + proteomic risk score 0.776). The developed proteomic risk score constitutes a new tool for stratifying patients according to hip fracture risk; however, its improvement in hip fracture discrimination is modest and its clinical utility beyond FRAX with information on femoral neck bone mineral density remains to be determined.
Details
- Title: Subtitle
- A plasma protein-based risk score to predict hip fractures
- Creators
- Thomas R Austin - University of WashingtonMaria Nethander - University of GothenburgHoward A Fink - Geriatric Research Education and Clinical CenterAnna E Törnqvist - University of GothenburgDiana I JalalPetra Buzkova - University of WashingtonJoshua I Barzilay - Kaiser PermanenteLaura Carbone - Charlie Norwood VA Medical CenterMaiken E Gabrielsen - Norwegian University of Science and TechnologyLouise Grahnemo - University of GothenburgTianyuan Lu - Jewish General HospitalKristian Hveem - Norwegian University of Science and TechnologyChristian Jonasson - Norwegian University of Science and TechnologyJorge R Kizer - San Francisco VA Health Care SystemArnulf LanghammerKenneth J Mukamal - Beth Israel Deaconess Medical CenterRobert E Gerszten - Beth Israel Deaconess Medical CenterBruce M Psaty - University of WashingtonJohn A Robbins - University of California, DavisYan V Sun - Emory UniversityAnne Heidi Skogholt - Norwegian University of Science and TechnologyJohn A KanisHelena Johansson - Australian Catholic UniversityBjørn Olav Åsvold - Norwegian University of Science and TechnologyRodrigo J Valderrabano - Brigham and Women's HospitalJie Zheng - Ruijin HospitalJ Brent Richards - McGill UniversityEivind Coward - Norwegian University of Science and TechnologyClaes Ohlsson - Sahlgrenska University Hospital
- Resource Type
- Journal article
- Publication Details
- Nature aging, Vol.4(8), pp.1064-1075
- DOI
- 10.1038/s43587-024-00639-7
- PMID
- 38802582
- PMCID
- PMC11333168
- NLM abbreviation
- Nat Aging
- eISSN
- 2662-8465
- Language
- English
- Electronic publication date
- 05/27/2024
- Date published
- 08/2024
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984630758902771
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