A possible association of recurrent streptococcal infections and acute onset of obsessive-compulsive disorder

Suck Won Kim; Jon E Grant; Sandra I Kim; Todd A Swanson; Gail A Bernstein; Waclaw B Jaszcz; Kyle A Williams; Patrick M Schlievert

doi:10.1176/appi.neuropsych.16.3.252

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A possible association of recurrent streptococcal infections and acute onset of obsessive-compulsive disorder

Journal article

Peer reviewed

A possible association of recurrent streptococcal infections and acute onset of obsessive-compulsive disorder

Suck Won Kim, Jon E Grant, Sandra I Kim, Todd A Swanson, Gail A Bernstein, Waclaw B Jaszcz, Kyle A Williams and Patrick M Schlievert

The journal of neuropsychiatry and clinical neurosciences, Vol.16(3), pp.252-260

2004

DOI: 10.1176/appi.neuropsych.16.3.252

PMID: 15377732

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Abstract

Rheumatic fever is an immunologically mediated disease that follows infection by group A beta-hemolytic Streptococcus (GABHS). In rheumatic fever, antibodies generated against GABHS cross-react with the heart, joints, skin, and other sites, inducing an inflammatory, multisystem disease. Brain tissue-specific antibodies have been demonstrated in a subset of children with Sydenham chorea (a component of the Jones criteria for the diagnosis of rheumatic fever), and most Sydenham chorea patients manifest obsessive-compulsive symptoms very similar to those in traditional obsessive-compulsive disorder. The parallels drawn from the paradigm of Sydenham's chorea to Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) is an area of active controversy. Newly emerging information on the role of GABHS superantigens in the pathogenesis of rheumatic fever is of particular interest. In this article, we review the microbial characteristics of GABHS and the subsequent immune responses to GABHS as a possible etiology of PANDAS.

Hemolysin Proteins - immunology

Humans

Obsessive-Compulsive Disorder - immunology

Antibodies, Monoclonal

Autoimmune Diseases - etiology

Obsessive-Compulsive Disorder - microbiology

Bacterial Proteins

Brain - metabolism

Autoimmune Diseases - microbiology

Biomarkers

Nervous System Diseases - etiology

Streptococcal Infections - complications

Antistreptolysin - biosynthesis

Brain - immunology

Obsessive-Compulsive Disorder - etiology

Nervous System Diseases - microbiology

Details

Title: Subtitle: A possible association of recurrent streptococcal infections and acute onset of obsessive-compulsive disorder
Creators: Suck Won Kim - Department of Psychiatry, University of Minnesota Medical School, Minneapolis, Minnesota, USA. kimxx003@tc.umn.edu
Jon E Grant
Sandra I Kim
Todd A Swanson
Gail A Bernstein
Waclaw B Jaszcz
Kyle A Williams
Patrick M Schlievert
Resource Type: Journal article
Publication Details: The journal of neuropsychiatry and clinical neurosciences, Vol.16(3), pp.252-260
Publisher: United States
DOI: 10.1176/appi.neuropsych.16.3.252
PMID: 15377732
ISSN: 0895-0172
eISSN: 1545-7222
Language: English
Date published: 2004
Academic Unit: Microbiology and Immunology; Internal Medicine
Record Identifier: 9984001143602771

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