Journal article
A preliminary investigation of Beta-hCG expression in patients with osteosarcoma
Journal of bone and joint surgery. British volume, Vol.94B(3), pp.419-424
03/01/2012
DOI: 10.1302/0301-620X.94B3.27679
PMID: 22371553
Abstract
There are eight reported cases in the literature of osteosarcomas secreting beta-hCG. Our primary aim was to investigate the rate of beta-hCG expression in osteosarcoma and attempt to understand the characteristics of osteosarcomas that secrete beta-hCG. We reviewed 37 histopathology slides (14 biopsies and 23 surgical specimens) from 32 patients with osteosarcoma. The slides were retrospectively stained for beta-hCG expression. Patient and tumour characteristics, including age, gender, tumour location, subtype, proportion of necrosis, presence of metastases and recurrence were recorded. A total of five of the 32 tumours were found to be positive for beta-hCG expression (one strongly and four weakly). This incidence of this expression was found in tumours with poor histological response to neoadjuvant chemotherapy.
The use of beta-hCG expression as a diagnostic, prognostic or follow-up marker is questionable and needs further investigation with a larger sample size.
Details
- Title: Subtitle
- A preliminary investigation of Beta-hCG expression in patients with osteosarcoma
- Creators
- K. Z. Masrouha - American University of Beirut Medical CenterR. Khattab - American University of BeirutA. Tawil - American University of Beirut Medical CenterA. Abdallah - American University of BeirutS. Saghieh - American University of BeirutR. Haidar - American University of Beirut Medical CenterM. Abboud - American University of Beirut Medical CenterN. J. Khoury - American University of Beirut Medical Center
- Resource Type
- Journal article
- Publication Details
- Journal of bone and joint surgery. British volume, Vol.94B(3), pp.419-424
- Publisher
- British Editorial Soc Bone Joint Surgery
- DOI
- 10.1302/0301-620X.94B3.27679
- PMID
- 22371553
- ISSN
- 0301-620X
- eISSN
- 2044-5377
- Number of pages
- 6
- Grant note
- Lebanese Ministry of Health St. Jude Children's Research Hospital, Memphis, Tennessee Board of Trustees of the Children's Cancer Center of Lebanon Foundation
- Language
- English
- Date published
- 03/01/2012
- Academic Unit
- Radiology
- Record Identifier
- 9984697721402771
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