Journal article
A prevalence-based association test for case-control studies
Genetic epidemiology, Vol.32(7), pp.600-605
11/2008
DOI: 10.1002/gepi.20342
PMID: 18473366
Abstract
Genetic association is often determined in case-control studies by the differential distribution of alleles or genotypes. Recent work has demonstrated that association can also be assessed by deviations from the expected distributions of alleles or genotypes. Specifically, multiple methods motivated by the principles of Hardy-Weinberg equilibrium (HWE) have been developed. However, these methods do not take into account many of the assumptions of HWE. Therefore, we have developed a prevalence-based association test (PRAT) as an alternative method for detecting association in case-control studies. This method, also motivated by the principles of HWE, uses an estimated population allele frequency to generate expected genotype frequencies instead of using the case and control frequencies separately. Our method often has greater power, under a wide variety of genetic models, to detect association than genotypic, allelic or Cochran-Armitage trend association tests. Therefore, we propose PRAT as a powerful alternative method of testing for association
Details
- Title: Subtitle
- A prevalence-based association test for case-control studies
- Creators
- Kelli K Ryckman - Center for Human Genetics Research, Vanderbilt University, Nashville, TennesseeLan Jiang - Center for Human Genetics Research, Vanderbilt University, Nashville, TennesseeChun Li - Center for Human Genetics Research, Vanderbilt University, Nashville, TennesseeJacquelaine Bartlett - Center for Human Genetics Research, Vanderbilt University, Nashville, TennesseeJonathan L Haines - Center for Human Genetics Research, Vanderbilt University, Nashville, TennesseeScott M Williams - Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee
- Resource Type
- Journal article
- Publication Details
- Genetic epidemiology, Vol.32(7), pp.600-605
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- DOI
- 10.1002/gepi.20342
- PMID
- 18473366
- ISSN
- 0741-0395
- eISSN
- 1098-2272
- Number of pages
- 7
- Language
- English
- Date published
- 11/2008
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology
- Record Identifier
- 9984216626202771
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