A probabilistic histological atlas of the human brain for MRI segmentation
Abstract
Details
- Title: Subtitle
- A probabilistic histological atlas of the human brain for MRI segmentation
- Creators
- Adrià Casamitjana - Universitat de GironaMatteo Mancini - University College LondonEleanor Robinson - University College LondonLoïc Peter - University College LondonRoberto Annunziata - University College LondonJuri Althonayan - University College LondonShauna Crampsie - University College LondonEmily Blackburn - University College LondonBenjamin Billot - University College LondonAlessia Atzeni - University College LondonOula Puonti - Copenhagen University HospitalYaël Balbastre - University College LondonPeter Schmidt - University College LondonJames Hughes - University College LondonJean C Augustinack - Athinoula A. Martinos Center for Biomedical ImagingBrian L Edlow - Massachusetts General HospitalLilla Zöllei - Athinoula A. Martinos Center for Biomedical ImagingDavid L Thomas - National Hospital for Neurology and NeurosurgeryDorit Kliemann - University of IowaMartina Bocchetta - National Hospital for Neurology and NeurosurgeryCatherine Strand - University College LondonJanice L Holton - University College LondonZane Jaunmuktane - University College LondonJuan Eugenio Iglesias - Massachusetts General Hospital
- Resource Type
- Journal article
- Publication Details
- Nature (London), Vol.648(8094), pp.678-685
- DOI
- 10.1038/s41586-025-09708-2
- PMID
- 41193801
- PMCID
- PMC12711564
- NLM abbreviation
- Nature
- ISSN
- 1476-4687
- eISSN
- 1476-4687
- Publisher
- Springer Nature
- Grant note
- Alzheimer's Disease Neuroimaging Initiative (National Institutes of Health): U01 AG024904 DOD ADNI (Department of Defense): W81XWH-12-2-0012 National Institute on AgingNational Institute of Biomedical Imaging and BioengineeringAlzheimer's AssociationAlzheimer's Drug Discovery FoundationAraclon BiotechBiogenBristol-Myers Squibb CompanyCereSpir, Inc.CogstateElan Pharmaceuticals, Inc.Eli Lilly and CompanyEuroImmunF. Hoffmann-La Roche LtdFujirebioJohnson & Johnson Pharmaceutical Research & Development LLC.Merck Co., Inc.Meso Scale DiagnosticsNeuroRx ResearchNovartis Pharmaceuticals CorporationPfizer Inc.Piramal ImagingTakeda Pharmaceutical CompanyCanadian Institutes of Health ResearchADNI clinical sites in CanadaFoundation for the National Institutes of HealthNorthern California Institute for Research and EducationLaboratory for Neuro Imaging at the University of Southern California - European Research Council: 677697, POSTDOC-UdG203 Universitat de GironaAlzheimer's Society, UK: AS-JF-19a-004-517 Lundbeck foundation: R360-2021-39 Italian National Institute of HealthWellcome Trust through a Sir Henry Wellcome Fellowship: 213722/Z/18/Z Chen Institute MGH Research Scholar AwardNIH: 1RF1MH123195, 1R01AG070988, 1UM1MH130981, 1RF1AG080371, 1R21NS109627
We would like to thank the donors, without whom this work would have not been possible. We would also like to acknowledge P. Johns for his invaluable courses in neuroanatomy at St George's, University of London. Data collection and sharing for the ADNI data used in this article was funded by the Alzheimer's Disease Neuroimaging Initiative (National Institutes of Health grant no. U01 AG024904) and DOD ADNI (Department of Defense grant no. W81XWH-12-2-0012). ADNI is funded by the National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering and through generous contributions from the following: AbbVie, Alzheimer's Association; Alzheimer's Drug Discovery Foundation; Araclon Biotech; BioClinica, Inc.; Biogen; Bristol-Myers Squibb Company; CereSpir, Inc.; Cogstate; Eisai Inc.; Elan Pharmaceuticals, Inc.; Eli Lilly and Company; EuroImmun; F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.; Fujirebio; GE Healthcare; IXICO Ltd.; Janssen Alzheimer Immunotherapy Research & Development, LLC.; Johnson & Johnson Pharmaceutical Research & Development LLC.; Lumosity; Lundbeck; Merck & Co., Inc.; Meso Scale Diagnostics, LLC.; NeuroRx Research; Neurotrack Technologies; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Piramal Imaging; Servier; Takeda Pharmaceutical Company; and Transition Therapeutics. The Canadian Institutes of Health Research is providing funds to support ADNI clinical sites in Canada. Private sector contributions are facilitated by the Foundation for the National Institutes of Health (www.fnih.org). The grantee organization is the Northern California Institute for Research and Education, and the study is coordinated by the Alzheimer's Therapeutic Research Institute at the University of Southern California. ADNI data are disseminated by the Laboratory for Neuro Imaging at the University of Southern California. This research has been primarily funded by the European Research Council awarded to J.E.I. (Starting grant no. 677697, project 'BUNGEE-TOOLS'). A.C. is supported by the POSTDOC-UdG203 grant from Universitat de Girona. M.B. is supported by a Fellowship award from the Alzheimer's Society, UK (grant no. AS-JF-19a-004-517). O.P. is supported by a grant from the Lundbeck foundation (grant no. R360-2021-39). M.M. is supported by the Italian National Institute of Health with a Starting Grant and by the Wellcome Trust through a Sir Henry Wellcome Fellowship (grant no. 213722/Z/18/Z). B.L.E. is supported by the Chen Institute MGH Research Scholar Award. Further support was provided by NIH grant nos. 1RF1MH123195, 1R01AG070988, 1UM1MH130981, 1RF1AG080371 and 1R21NS109627.
- Language
- English
- Electronic publication date
- 11/05/2025
- Date published
- 12/18/2025
- Academic Unit
- Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9985024259902771