Journal article
A proposal for comprehensive newborn hearing screening to improve identification of deaf and hard-of-hearing children
Genetics in medicine, Vol.21(11), pp.2614-2630
11/2019
DOI: 10.1038/s41436-019-0563-5
PMCID: PMC6831511
PMID: 31171844
Abstract
Early intervention for newborns who are deaf or hard-of-hearing leads to improved language, communication, and social-emotional outcomes. Universal physiologic newborn hearing screening has been widely implemented across the United States with the goal of identifying newborns who are deaf or hard-of-hearing, thereby reducing time to diagnosis and intervention. The current physiologic newborn hearing screen is generally successful in accomplishing its goals but improvements could be made. In the past ten years, genetic testing has emerged as the most important etiological diagnostic test for evaluation of children with deafness and congenital cytomegalovirus has been recognized as a major cause of childhood deafness that may be treatable. A comprehensive newborn hearing screen that includes physiologic, genetic, and cytomegalovirus testing would have multiple benefits, including (1) identifying newborns with deafness missed by the current physiologic screen, (2) providing etiologic information, and (3) possibly decreasing the number of children lost to follow up. We present a framework for integrating limited genetic testing and cytomegalovirus screening into the current physiologic newborn hearing screening. We identify needed areas of research and include an overview of genome sequencing, which we believe will become available over the next decade as a complement to universal physiologic newborn hearing screening.
Details
- Title: Subtitle
- A proposal for comprehensive newborn hearing screening to improve identification of deaf and hard-of-hearing children
- Creators
- A Eliot Shearer - University of Iowa Hospitals and ClinicsJun Shen - Brigham and Women's HospitalSami Amr - Brigham and Women's HospitalCynthia C Morton - Brigham and Women's HospitalRichard J Smith - University of Iowa Hospitals and ClinicsNewborn Hearing Screening Working Group of the National Coordinating Center for the Regional Genetics Networks
- Resource Type
- Journal article
- Publication Details
- Genetics in medicine, Vol.21(11), pp.2614-2630
- DOI
- 10.1038/s41436-019-0563-5
- PMID
- 31171844
- PMCID
- PMC6831511
- ISSN
- 1098-3600
- eISSN
- 1530-0366
- Grant note
- R01 DC015052 / NIDCD NIH HHS
- Language
- English
- Date published
- 11/2019
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
- Record Identifier
- 9984256836602771
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