Journal article
A prospective study of antibiotic use and associated infections in young children
Paediatric and perinatal epidemiology, Vol.15(1), pp.61-67
01/2001
DOI: 10.1046/j.1365-3016.2001.00326.x
PMID: 11237117
Abstract
This study examines antibiotic usage and associated infections in infants and young children in Iowa. Longitudinal data were collected using a cohort recruited at birth from eight hospitals in eastern Iowa. Parents of recruited children were mailed questionnaires at 6 weeks, and 3, 6, 9, 12, 16, and 20 months of age. The cumulative incidence of antibiotic use and associated infections was determined using Kaplan-Meier survival analysis. There were data on 1,368 children. Antibiotic use was common in our cohort and increased with age. Beginning at age 3 months, approximately 50% of the cohort was exposed to an antibiotic during each reporting period. Otitis media was the most common indication and was responsible for 67.3% of antibiotic use. Children were most frequently treated with amoxicillin, followed by the cephalosporins and sulphonamides. By 12 and 20 months of age 79.0% and 92.5% of the children, respectively, had been treated with at least one course of antibiotics. Children received antibiotics for a median of 43 days by 20 months of age. Males were more likely to experience any antibiotic exposure than females (hazard ratio = 1.18) and showed a trend for more days of use (P = 0.052). There was a small but significant variation in antibiotic usage in the different recruitment communities (P = 0.02).
Details
- Title: Subtitle
- A prospective study of antibiotic use and associated infections in young children
- Creators
- G R Bergus - Department of Family Medicine, The Colleges of Medicine and Dentistry, University of Iowa, Iowa City 52242, USA. george-bergus@uiowa.eduS M LevyH L KirchnerJ J WarrenB T Levy
- Resource Type
- Journal article
- Publication Details
- Paediatric and perinatal epidemiology, Vol.15(1), pp.61-67
- Publisher
- England
- DOI
- 10.1046/j.1365-3016.2001.00326.x
- PMID
- 11237117
- ISSN
- 0269-5022
- eISSN
- 1365-3016
- Grant note
- P30-DE10126 / NIDCR NIH HHS R01-DE09551 / NIDCR NIH HHS
- Language
- English
- Date published
- 01/2001
- Academic Unit
- Preventive and Community Dentistry; Physician Assistant Studies; Psychiatry; Epidemiology; Family and Community Medicine
- Record Identifier
- 9983917682102771
Metrics
24 Record Views