Journal article
A prospective trial of adjuvant therapy for high-risk uveal melanoma: assessing 5-year survival outcomes
British journal of ophthalmology, Vol.104(4), pp.524-528
04/2020
DOI: 10.1136/bjophthalmol-2019-314461
PMID: 31371315
Abstract
Survival after diagnosis of metastasis from uveal melanoma is poor. Identifying individuals at high risk for metastasis and developing adjuvant therapy to prevent clinically apparent metastasis could improve survival. We conducted an adjuvant trial of sequential, low-dose dacarbazine (DTIC) and interferon-alpha-2b (IFN-α-2b) in patients with cytogenetic high-risk uveal melanoma.
Patients diagnosed with iris, ciliary body or choroidal melanoma with high-risk tumour cytogenetics (monosomy 3) were offered adjuvant treatment with low-dose DTIC and IFN-α-2b following primary therapy. Eligible but not enrolled patients were observed for comparison. DTIC was administered at 850 mg/m
intravenously on days 1 and 28. IFN-α-2b was administered at 3 million units three times a week subcutaneously for 24 weeks beginning at week 9. Hepatic imaging was performed prior to adjuvant therapy and then at least every 6 months. Survival data were collected for 5 years after enrolment.
33 patients (22%) were enrolled (treatment group), 29 (19%) were eligible but did not enrol (observation group) and 88 (59%) were not eligible. The 5-year metastasis-free survival (MFS) was 64%±9% for treated and 33%±10% for observed patients (p=0.05). The 5-year overall survival (OS) rate was 66%±9% for treated and 37%±10% for observed patients (p=0.02).
When adjusted for differences in age, tumour size and initial treatment, survival between treated and observed patients was no longer significant (p=0.56 MFS and p=0.92 OS). Differences in baseline tumour characteristics between treated and observed patients can influence interpretation of results.
NCT01100528.
Details
- Title: Subtitle
- A prospective trial of adjuvant therapy for high-risk uveal melanoma: assessing 5-year survival outcomes
- Creators
- Elaine Binkley - Department of Ophthalmic Oncology, Cleveland Clinic, Cole Eye Institute, Cleveland, Ohio, USAPierre L Triozzi - Department of Hematology Oncolgy, Wake Forest University, Winston Salem, North Carolina, USALisa Rybicki - Department of Ophthalmic Oncology, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USASusan Achberger - Department of Ophthalmic Oncology, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USAWayne Aldrich - Department of Ophthalmic Oncology, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USAArun Singh - Department of Ophthalmic Oncology, Cleveland Clinic, Cole Eye Institute, Cleveland, Ohio, USA singha@ccf.org
- Resource Type
- Journal article
- Publication Details
- British journal of ophthalmology, Vol.104(4), pp.524-528
- DOI
- 10.1136/bjophthalmol-2019-314461
- PMID
- 31371315
- ISSN
- 0007-1161
- eISSN
- 1468-2079
- Grant note
- name: Ratner Foundation; name: Falk Trust; DOI: 10.13039/100000054, name: National Cancer Institute, award: RO1CA136776; DOI: 10.13039/100001818, name: Research to Prevent Blindness
- Language
- English
- Date published
- 04/2020
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9984102315502771
Metrics
25 Record Views