Journal article
A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease
Neurology, Vol.88(2), pp.152-159
01/10/2017
DOI: 10.1212/WNL.0000000000003478
PMCID: PMC5224719
PMID: 27913695
Abstract
To test the hypothesis that chronic treatment of early-stage Huntington disease (HD) with high-dose coenzyme Q10 (CoQ) will slow the progressive functional decline of HD.
We performed a multicenter randomized, double-blind, placebo-controlled trial. Patients with early-stage HD (n = 609) were enrolled at 48 sites in the United States, Canada, and Australia from 2008 to 2012. Patients were randomized to receive either CoQ 2,400 mg/d or matching placebo, then followed for 60 months. The primary outcome variable was the change from baseline to month 60 in Total Functional Capacity score (for patients who survived) combined with time to death (for patients who died) analyzed using a joint-rank analysis approach.
An interim analysis for futility revealed a conditional power of <5% for the primary analysis, prompting premature conclusion in July 2014. No statistically significant differences were seen between treatment groups for the primary or secondary outcome measures. CoQ was generally safe and well-tolerated throughout the study.
These data do not justify use of CoQ as a treatment to slow functional decline in HD.
NCT00608881.
This article provides Class I evidence that CoQ does not slow the progressive functional decline of patients with HD.
Details
- Title: Subtitle
- A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease
- Creators
- Andrew McGarry - Rowan UniversityMichael McDermott - University of RochesterKarl Kieburtz - University of RochesterElisabeth A de BlieckFlint Beal - Cornell UniversityKaren Marder - Columbia UniversityChristopher Ross - Johns Hopkins UniversityIra Shoulson - Georgetown UniversityPeter Gilbert - National Institutes of HealthWilliam M MalloneeMark GuttmanJoanne Wojcieszek - Indiana UniversityRajeev KumarMark S LeDoux - University of Tennessee Health Science CenterMary Jenkins - London Health Sciences CentreH Diana Rosas - Harvard UniversityMartha NanceKevin Biglan - University of RochesterPeter Como - University of RochesterRichard M Dubinsky - University of KansasKathleen M Shannon - Rush University Medical CenterPadraig O'Suilleabhain - The University of Texas Southwestern Medical CenterKelvin Chou - University of MichiganFrancis Walker - Wake Forest UniversityWayne MartinVicki L Wheelock - University of California, DavisElizabeth McCusker - Westmead HospitalJoseph Jankovic - Baylor College of MedicineCarlos Singer - University of MiamiJuan Sanchez-Ramos - University of South FloridaBurton Scott - Duke UniversityOksana Suchowersky - University of CalgaryStewart A Factor - Emory UniversityDonald S Higgins JrEric Molho - Albany Medical Center HospitalFredy Revilla - University of CincinnatiJohn N Caviness - Mayo ClinicJoseph H Friedman - Brown UniversityJoel S Perlmutter - Washington University in St. LouisAndrew Feigin - Northwell HealthKaren Anderson - Georgetown UniversityRamon Rodriguez - University of FloridaNikolaus R McFarland - University of FloridaRussell L Margolis - Johns Hopkins UniversityEric S Farbman - University of Nevada, RenoLynn A Raymond - University of British ColumbiaValerie Suski - University of PittsburghSandra Kostyk - The Ohio State UniversityAmy Colcher - University Health SystemLauren SeebergerEric Epping - University of IowaSherali Esmail - University of TorontoNancy Diaz - St. Luke's-Roosevelt Hospital CenterWai Lun Alan Fung - University of TorontoAlan DiamondSamuel Frank - Harvard UniversityPhilip HannaNeal Hermanowicz - University of California, IrvineLeon S Dure - University of Alabama at BirminghamMerit Cudkowicz - Harvard UniversityHuntington Study Group 2CARE Investigators and Coordinators
- Resource Type
- Journal article
- Publication Details
- Neurology, Vol.88(2), pp.152-159
- DOI
- 10.1212/WNL.0000000000003478
- PMID
- 27913695
- PMCID
- PMC5224719
- NLM abbreviation
- Neurology
- ISSN
- 0028-3878
- eISSN
- 1526-632X
- Grant note
- U01 NS052592 / NINDS NIH HHS R01 NS052619 / NINDS NIH HHS R01 NS052592 / NINDS NIH HHS R56 NS042861 / NINDS NIH HHS
- Language
- English
- Date published
- 01/10/2017
- Academic Unit
- Psychiatry
- Record Identifier
- 9984288743602771
Metrics
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