Journal article
A randomized multicenter trial comparing the GlucoWatch Biographer with standard glucose monitoring in children with type 1 diabetes
Diabetes care, Vol.28(5), pp.1101-1106
05/2005
DOI: 10.2337/diacare.28.5.1101
PMID: 15855573
Abstract
This study assesses whether use of the GlucoWatch G2 Biographer (GW2B) in addition to standard glucose monitoring lowers HbA(1c) and reduces hypoglycemia compared with standard glucose monitoring alone.
In all, 200 subjects aged 7 to <18 years with type 1 diabetes were randomly assigned at five centers to standard glucose monitoring (usual care) or standard glucose monitoring plus GW2B use for 6 months. Study outcomes included HbA(1c) values obtained at 6 months and occurrence of severe hypoglycemia.
The mean HbA(1c) at baseline was 8.0% in both groups; at 6 months, HbA(1c) was 7.9% in the usual care group and 8.1% in the GW2B group (95% CI for mean reduction in the GW2B group compared with the usual care group -0.4 to 0.1%; P = 0.15). A decrease in HbA(1c) of > or =0.5% was achieved in 21% of the usual care group and 28% of the GW2B group (P = 0.29). Severe hypoglycemia events occurred in 7% of the GW2B group and in 2% of the usual care group (P = 0.10). In the GW2B group, sensor use declined throughout the study from a mean value of 2.1 times/week in the 1st month to 1.5 times/week in the 6th month. Reasons given for declining use included skin irritation (76%), frequent skips (56%), excessive alarms (47%), and inaccurate readings (33%).
Use of the GW2B in addition to standard glucose monitoring did not improve glycemic control or reduce the frequency of severe hypoglycemia. Skin reactions and other problems led to decreasing sensor use over time.
Details
- Title: Subtitle
- A randomized multicenter trial comparing the GlucoWatch Biographer with standard glucose monitoring in children with type 1 diabetes
- Creators
- H Peter Chase - DirecNet Coordinating Center, Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, FL 33647, USA. direcnet@jaeb.orgRoy BeckWilliam TamborlaneBruce BuckinghamNelly MaurasEva TsalikianTim WysockiStuart WeinzimerCraig KollmanKatrina RuedyDongyuan XingDiabetes Research in Children Network (DirecNet) Study Group
- Resource Type
- Journal article
- Publication Details
- Diabetes care, Vol.28(5), pp.1101-1106
- DOI
- 10.2337/diacare.28.5.1101
- PMID
- 15855573
- ISSN
- 0149-5992
- eISSN
- 1935-5548
- Grant note
- HD 041919-01 / NICHD NIH HHS HD 041918-01 / NICHD NIH HHS HD 041908-01 / NICHD NIH HHS HD 041915-01 / NICHD NIH HHS HD 041906-01 / NICHD NIH HHS HD 041890 / NICHD NIH HHS
- Language
- English
- Date published
- 05/2005
- Academic Unit
- Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984093312302771
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