Journal article
A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease
Neurology, Vol.57(3), pp.397-404
08/14/2001
DOI: 10.1212/WNL.57.3.397
PMID: 11502903
Abstract
OBJECTIVESTo determine whether chronic treatment with coenzyme Q10 or remacemide hydrochloride slows the functional decline of early Huntington's disease (HD).METHODSThe authors conducted a multicenter, parallel group, double-blind, 2 x 2 factorial, randomized clinical trial. Research participants with early HD (n = 347) were randomized to receive coenzyme Q10 300 mg twice daily, remacemide hydrochloride 200 mg three times daily, both, or neither treatment, and were evaluated every 4 to 5 months for a total of 30 months on assigned treatment. The prespecified primary measure of efficacy was the change in total functional capacity (TFC) between baseline and 30 months. Safety measures included the frequency of clinical adverse events.RESULTSNeither intervention significantly altered the decline in TFC. Patients treated with coenzyme Q10 showed a trend toward slowing in TFC decline (13%) over 30 months (2.40- versus 2.74-point decline, p = 0.15), as well as beneficial trends in some secondary measures. There was increased frequency of nausea, vomiting, and dizziness with remacemide and increased frequency of stomach upset with coenzyme Q10.CONCLUSIONSNeither remacemide nor coenzyme Q10, at the dosages studied, produced significant slowing in functional decline in early HD.
Details
- Title: Subtitle
- A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease
- Creators
- Huntington Study Group
- Contributors
- Jane S Paulsen (Contributor) - University of Iowa, Psychological and Brain Sciences
- Resource Type
- Journal article
- Publication Details
- Neurology, Vol.57(3), pp.397-404
- DOI
- 10.1212/WNL.57.3.397
- PMID
- 11502903
- ISSN
- 0028-3878
- eISSN
- 1526-632X
- Language
- English
- Date published
- 08/14/2001
- Academic Unit
- Psychiatry; Psychological and Brain Sciences
- Record Identifier
- 9984083214502771
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