Journal article
A randomized single-blind trial of standard diet versus fiber-free diet with polyethylene glycol electrolyte solution for colonoscopy preparation
Endoscopy, Vol.42(8), pp.633-638
2010
DOI: 10.1055/s-0029-1244236
PMID: 20623443
Abstract
Background and study aims: Colonoscopy preparation usually involves the intake of large volumes of polyethylene glycol electrolyte solution (PEG-ES) in combination with a clear-liquid diet (CLD). Liberalization of the diet might enhance the tolerance to PEG-ES without compromising the quality of the preparation. The primary aims of this study were to evaluate the efficacy and tolerability of PEG-ES given with a CLD compared with a fiber-free diet (FFD) for colonoscopy preparation. The incidence of adverse events among patients in the two diet groups was also assessed as a secondary outcome.
Methods: This was a single-center randomized, prospective, single-blind study. A total of 200 patients undergoing colonoscopy were randomized to either CLD or FFD in addition to PEG-ES.
Results: Patients in the FFD group were able to drink more PEG-ES (mean ± SD, 3.9 ± 0.3 L) compared with those in the CLD group (3.3 ± 0.7 L) (P < 0.01). The quality of the preparation was significantly better in the FFD group, with more patients having satisfactory preparations than those in the CLD group (81.4 % vs. 52.0 %; P < 0.001). Tolerance to the preparation was higher in the FFD group compared with the CLD group, with significantly more patients adhering to the FFD regimen (P < 0.001). There were more adverse events experienced in the CLD group, with odds ratios of 1.9 for nausea (95 % confidence interval [CI] 1.0 – 3.6), 3.8 for vomiting (95 % CI 1.3 – 11.3), and 3.0 for headache (95 % CI 1.5 – 5.9).
Conclusion: FFD given with PEG-ES on the day before colonoscopy is a more effective regimen than the standard CLD regimen, and is better tolerated by patients.
Details
- Title: Subtitle
- A randomized single-blind trial of standard diet versus fiber-free diet with polyethylene glycol electrolyte solution for colonoscopy preparation
- Creators
- A. M SOWEID - Department of Internal Medicine, American University of Beirut Medical Center, Beirut, LebanonA. A KOBEISSY - Department of Internal Medicine, American University of Beirut Medical Center, Beirut, LebanonF MOURAD - Department of Internal Medicine, American University of Beirut Medical Center, Beirut, LebanonA ARABI - Department of Internal Medicine, American University of Beirut Medical Center, Beirut, LebanonF. R JAMALI - Department of Surgery, American University of Beirut Medical Center, Beirut, LebanonM EL-TARCHICHI - Department of Internal Medicine, American University of Beirut Medical Center, Beirut, LebanonA SKOURY - Department of Internal Medicine, American University of Beirut Medical Center, Beirut, LebanonH ABDUL-BAKI - Department of Internal Medicine, American University of Beirut Medical Center, Beirut, LebanonL EL-ZAHABI - Department of Internal Medicine, American University of Beirut Medical Center, Beirut, LebanonA EL-SAYYED - Department of Internal Medicine, American University of Beirut Medical Center, Beirut, LebanonK. A BARADA - Department of Internal Medicine, American University of Beirut Medical Center, Beirut, LebanonA. I SHARARA - Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
- Resource Type
- Journal article
- Publication Details
- Endoscopy, Vol.42(8), pp.633-638
- Publisher
- Thieme
- DOI
- 10.1055/s-0029-1244236
- PMID
- 20623443
- ISSN
- 0013-726X
- eISSN
- 1438-8812
- Language
- English
- Date published
- 2010
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984094574802771
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