A randomized trial of mexiletine in ALS: Safety and effects on muscle cramps and progression

Michael D Weiss; Eric A Macklin; Zachary Simmons; Angela S Knox; David J Greenblatt; Nazem Atassi; Michael Graves; Nicholas Parziale; Johnny S Salameh; Colin Quinn; Robert H Brown Jr; Jane B Distad; Jaya Trivedi; Jeremy M Shefner; Richard J Barohn; Alan Pestronk; Andrea Swenson; Merit E Cudkowicz

doi:10.1212/WNL.0000000000002507

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A randomized trial of mexiletine in ALS: Safety and effects on muscle cramps and progression

Journal article

Open access

Peer reviewed

A randomized trial of mexiletine in ALS: Safety and effects on muscle cramps and progression

Michael D Weiss, Eric A Macklin, Zachary Simmons, Angela S Knox, David J Greenblatt, Nazem Atassi, Michael Graves, Nicholas Parziale, Johnny S Salameh, Colin Quinn, …

Neurology, Vol.86(16), pp.1474-1481

04/19/2016

DOI: 10.1212/WNL.0000000000002507

PMCID: PMC4836879

PMID: 26911633

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Abstract

To determine the safety and tolerability of mexiletine in a phase II double-blind randomized controlled trial of sporadic amyotrophic lateral sclerosis (SALS).

Muscle Cramp - physiopathology

Voltage-Gated Sodium Channel Blockers - pharmacokinetics

Amyotrophic Lateral Sclerosis - physiopathology

Follow-Up Studies

Humans

Mexiletine - pharmacokinetics

Middle Aged

Mexiletine - therapeutic use

Male

Treatment Outcome

Postural Balance - drug effects

Amyotrophic Lateral Sclerosis - drug therapy

Disease Progression

Dose-Response Relationship, Drug

Mexiletine - adverse effects

Voltage-Gated Sodium Channel Blockers - therapeutic use

Female

Muscle Cramp - drug therapy

Voltage-Gated Sodium Channel Blockers - adverse effects

Details

Title: Subtitle: A randomized trial of mexiletine in ALS: Safety and effects on muscle cramps and progression
Creators: Michael D Weiss
Eric A Macklin
Zachary Simmons
Angela S Knox
David J Greenblatt
Nazem Atassi
Michael Graves
Nicholas Parziale
Johnny S Salameh
Colin Quinn
Robert H Brown Jr
Jane B Distad
Jaya Trivedi
Jeremy M Shefner
Richard J Barohn
Alan Pestronk
Andrea Swenson
Merit E Cudkowicz
Resource Type: Journal article
Publication Details: Neurology, Vol.86(16), pp.1474-1481
DOI: 10.1212/WNL.0000000000002507
PMID: 26911633
PMCID: PMC4836879
NLM abbreviation: Neurology
ISSN: 0028-3878
eISSN: 1526-632X
Publisher: United States
Language: English
Date published: 04/19/2016
Academic Unit: Neurology
Record Identifier: 9984020640602771

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