Journal article
A randomized trial to evaluate 2 hours of daily patching for strabismic and anisometropic amblyopia in children
Ophthalmology (Rochester, Minn.), Vol.113(6), pp.904-912
06/2006
DOI: 10.1016/j.ophtha.2006.01.069
PMCID: PMC1609192
PMID: 16751033
Abstract
To compare 2 hours of daily patching (combined with 1 hour of concurrent near visual activities) with a control group of spectacle wear alone (if needed) for treatment of moderate to severe amblyopia in children 3 to 7 years old. Prospective randomized multicenter clinical trial (46 sites). One hundred eighty children 3 to 7 years old with best-corrected amblyopic-eye visual acuity (VA) of 20/40 to 20/400 associated with strabismus, anisometropia, or both who had worn optimal refractive correction (if needed) for at least 16 weeks or for 2 consecutive visits without improvement. Randomization either to 2 hours of daily patching with 1 hour of near visual activities or to spectacles alone (if needed). Patients were continued on the randomized treatment (or no treatment) until no further improvement was noted. Best-corrected VA in the amblyopic eye after 5 weeks. Improvement in VA of the amblyopic eye from baseline to 5 weeks averaged 1.1 lines in the patching group and 0.5 lines in the control group (P = 0.006), and improvement from baseline to best measured VA at any visit averaged 2.2 lines in the patching group and 1.3 lines in the control group (P<0.001). After a period of treatment with spectacles, 2 hours of daily patching combined with 1 hour of near visual activities modestly improves moderate to severe amblyopia in children 3 to 7 years old.
Details
- Title: Subtitle
- A randomized trial to evaluate 2 hours of daily patching for strabismic and anisometropic amblyopia in children
- Creators
- David K Wallace - Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, FL 33647, USA. pedig@jaeb.orgAllison R EdwardsSusan A CotterRoy W BeckRobert W ArnoldWilliam F AstleCarmen N BarnhardtEileen E BirchSean P DonahueDonald F EverettJoost FeliusJonathan M HolmesRaymond T KrakerMichele MeliaMichael X RepkaNicholas A SalaDavid I SilbertKatherine K WeisePediatric Eye Disease Investigator Group
- Contributors
- Richard J Olson (Contributor) - University of Iowa, Ophthalmology and Visual Sciences
- Resource Type
- Journal article
- Publication Details
- Ophthalmology (Rochester, Minn.), Vol.113(6), pp.904-912
- Publisher
- United States
- DOI
- 10.1016/j.ophtha.2006.01.069
- PMID
- 16751033
- PMCID
- PMC1609192
- ISSN
- 0161-6420
- eISSN
- 1549-4713
- Grant note
- U54 EB015408 / NIBIB NIH HHS EY11751 / NEI NIH HHS U10 EY011751 / NEI NIH HHS
- Language
- English
- Date published
- 06/2006
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9983979927602771
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