Journal article
A rash diagnosis: Gemcitabine-associated pseudocellulitis
Journal of oncology pharmacy practice, Vol.23(2), pp.157-160
03/01/2017
DOI: 10.1177/1078155216635852
PMID: 26946530
Abstract
Gemcitabine is an antitumor agent with broad clinical application. The most common cutaneous toxicities are mild rash and pruritus; however, a severe `pseudocellulitis' rash, which resembles infectious cellulitis in clinical presentation, has increasingly been recognized as a rare complication of this agent. Though the specific pathophysiology related to this condition is not clear, it has been observed to occur primarily in regions of significant lymphadenopathy or prior radiation exposure typically after 24-48 h following administration of gemcitabine. It is a self-limiting reaction, with most cases resolving within two to seven days of onset without any specific treatment for the rash. Treatment with gemcitabine may be safely continued in patients with this complication, though recurrence of the rash is common following repeated doses. We report a case of biopsy confirmed gemcitabine associated pseudocellulitis in a patient treated for metastatic pancreatic adenocarcinoma. Knowledge of this complication is important to avoid unwarranted hospitalizations and antibiotic use in patients treated with gemcitabine.
Details
- Title: Subtitle
- A rash diagnosis: Gemcitabine-associated pseudocellulitis
- Creators
- Christopher Strouse - Medical College of WisconsinNarendranath Epperla - Medical College of Wisconsin
- Resource Type
- Journal article
- Publication Details
- Journal of oncology pharmacy practice, Vol.23(2), pp.157-160
- Publisher
- Sage
- DOI
- 10.1177/1078155216635852
- PMID
- 26946530
- ISSN
- 1078-1552
- eISSN
- 1477-092X
- Number of pages
- 4
- Language
- English
- Date published
- 03/01/2017
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359787802771
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