A redox cycle within the cell cycle : ring in the old with the new

S. G MENON; P. C GOSWAMI

doi:10.1038/sj.onc.1209895

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A redox cycle within the cell cycle : ring in the old with the new

Journal article

Peer reviewed

A redox cycle within the cell cycle : ring in the old with the new

S. G MENON and P. C GOSWAMI

Oncogene, Vol.26(8), pp.1101-1109

2007

DOI: 10.1038/sj.onc.1209895

PMID: 16924237

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Abstract

In recent years, the intracellular oxidation-reduction (redox) state has gained increasing attention as a critical mediator of cell signaling, gene expression changes and proliferation. This review discusses the evidence for a redox cycle (i.e., fluctuation in the cellular redox state) regulating the cell cycle. The presence of redox-sensitive motifs (cysteine residues, metal co-factors in kinases and phosphatases) in several cell cycle regulatory proteins indicate periodic oscillations in intracellular redox state could play a central role in regulating progression from G0/G1 to S to G2 and M cell cycle phases. Fluctuations in the intracellular redox state during cell cycle progression could represent a fundamental mechanism linking oxidative metabolic processes to cell cycle regulatory processes. Proliferative disorders are central to a variety of human pathophysiological conditions thought to involve oxidative stress. Therefore, a more complete understanding of redox control of the cell cycle could provide a biochemical rationale for manipulating aberrant cell proliferation.

Cell Physiology

Fundamental and applied biological sciences. Psychology

Biological and medical sciences

Molecular and cellular biology

Cell cycle, cell proliferation

Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes

Details

Title: Subtitle: A redox cycle within the cell cycle : ring in the old with the new
Creators: S. G MENON - Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, IA, United States
P. C GOSWAMI - Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, IA, United States
Resource Type: Journal article
Publication Details: Oncogene, Vol.26(8), pp.1101-1109
DOI: 10.1038/sj.onc.1209895
PMID: 16924237
NLM abbreviation: Oncogene
ISSN: 0950-9232
eISSN: 1476-5594
Publisher: Nature Publishing; Basingstoke
Language: English
Date published: 2007
Academic Unit: Radiation Oncology
Record Identifier: 9984047608202771

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