A retrospective study of administration of vaccination for hepatitis B among newborn infants prior to hospital discharge at a midwestern tertiary care center

Helen I Myers; Cassandra N Spracklen; Kelli K Ryckman; Jeffrey C Murray

doi:10.1016/j.vaccine.2015.03.053

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A retrospective study of administration of vaccination for hepatitis B among newborn infants prior to hospital discharge at a midwestern tertiary care center

Journal article

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A retrospective study of administration of vaccination for hepatitis B among newborn infants prior to hospital discharge at a midwestern tertiary care center

Helen I Myers, Cassandra N Spracklen, Kelli K Ryckman and Jeffrey C Murray

Vaccine, Vol.33(20), pp.2316-2321

05/11/2015

DOI: 10.1016/j.vaccine.2015.03.053

PMCID: PMC4630806

PMID: 25835577

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Abstract

Infants are at high risk of developing chronic, life-threatening disease as a result of hepatitis B virus infection. Universal vaccination of infants against hepatitis B virus, before discharge from the hospital after delivery is recommended as a measure to eradicate infection and associated mortality and morbidity. The purpose of this study was to determine rates of perinatal hepatitis B vaccine (Hep B) administration at a tertiary care center in Iowa and to assess the impact of maternal factors on Hep B uptake. Data concerning mother–infant pairs that received care at one institution from 1/2009 to 4/1/2013 were extracted from the system's electronic medical record. Characteristics of study participants were compared using chi-square tests. Multivariate logistic regression was used to assess the association between each factor and vaccination status, controlling for other characteristics. Of 5663 mother–infant pairs, 5175 (91.4%) infants received Hep B within 7 days after delivery. The majority of those not vaccinated had a medical indication to delay vaccination. Single women were significantly more likely to have an infant not vaccinated, after adjustment for all other factors. Women of minority groups were significantly less likely to have an infant who lacked Hep B at hospital discharge than Caucasian women. Significant improvements have occurred in Hep B rates in the state and region. Infants of single mothers may be at the greatest risk for lacking vaccination at hospital discharge.

Immunization

Hepatitis B virus

Vaccination

Infant health

Details

Title: Subtitle: A retrospective study of administration of vaccination for hepatitis B among newborn infants prior to hospital discharge at a midwestern tertiary care center
Creators: Helen I Myers - University of Iowa Carver College of Medicine, Iowa City, IA, USA
Cassandra N Spracklen - University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Kelli K Ryckman - University of Iowa College of Public Health, Iowa City, IA, USA
Jeffrey C Murray - University of Iowa Carver College of Medicine, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Vaccine, Vol.33(20), pp.2316-2321
DOI: 10.1016/j.vaccine.2015.03.053
PMID: 25835577
PMCID: PMC4630806
NLM abbreviation: Vaccine
ISSN: 0264-410X
eISSN: 1873-2518
Publisher: Elsevier Ltd
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: 2 UL1 TR000442-06; DOI: 10.13039/100006108, name: National Center for Advancing Translational Sciences
Language: English
Date published: 05/11/2015
Academic Unit: Anatomy and Cell Biology; International Programs; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Nursing; Public Policy Center (Archive); Dental Research
Record Identifier: 9983995048202771

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