Journal article
A review of algorithmic techniques for disulfide-bond determination
Briefings in functional genomics & proteomics, Vol.7(2), pp.157-172
03/2008
DOI: 10.1093/bfgp/eln008
PMID: 18372287
Abstract
Disulfide bonds play an important role in understanding protein folding, evolution, and in studies related to determining structural and functional properties of specific proteins. At the state-of-the-art, a large number of computational techniques have been proposed for determining disulfide bonds. Operating across the gamut of input data, from pure sequence-based information to spectra from mass spectrometry, these techniques provide researchers with a variety of methodological choices and trade-offs. Techniques for disulfide-bond determination are also underpinned by a rich variety of algorithmic formulations. Analysis of these algorithms can provide valuable cues towards choosing a particular technique and understanding its results. Further, their study is critical in developing the next generation of techniques. This paper discusses the importance and applicability of disulfide-bond determination in understanding protein structure and function and provides a detailed review of computational approaches to this problem.
Details
- Title: Subtitle
- A review of algorithmic techniques for disulfide-bond determination
- Creators
- Rahul Singh - San Francisco State University
- Resource Type
- Journal article
- Publication Details
- Briefings in functional genomics & proteomics, Vol.7(2), pp.157-172
- DOI
- 10.1093/bfgp/eln008
- PMID
- 18372287
- ISSN
- 1473-9550
- eISSN
- 1477-4062
- Language
- English
- Date published
- 03/2008
- Academic Unit
- Computer Science
- Record Identifier
- 9984446457102771
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