Journal article
A review of metabolomics approaches and their application in identifying causal pathways of childhood asthma
Journal of allergy and clinical immunology, Vol.141(4), pp.1191-1201
04/2018
DOI: 10.1016/j.jaci.2017.04.021
PMCID: PMC5671382
PMID: 28479327
Abstract
Because asthma is a disease that results from host-environment interactions, an approach that allows assessment of the effect of the environment on the host is needed to understand the disease. Metabolomics has appealing potential as an application to study pathways to childhood asthma development. The objective of this review is to provide an overview of metabolomics methods and their application to understanding host-environment pathways in asthma development. We reviewed recent literature on advances in metabolomics and their application to study pathways to childhood asthma development. We highlight the (1) potential of metabolomics in understanding the pathogenesis of disease and the discovery of biomarkers; (2) choice of metabolomics techniques, biospecimen handling, and data analysis; (3) application to studying the role of the environment on asthma development; (4) review of metabolomics applied to the outcome of asthma; (5) recommendations for application of metabolomics-based -omics data integration in understanding disease pathogenesis; and (6) limitations. In conclusion, metabolomics allows use of biospecimens to identify useful biomarkers and pathways involved in disease development and subsequently to inform a greater understanding of disease pathogenesis and endotypes and prediction of the clinical course of childhood asthma phenotypes.
Details
- Title: Subtitle
- A review of metabolomics approaches and their application in identifying causal pathways of childhood asthma
- Creators
- Kedir N Turi - Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TennLindsey Romick-Rosendale - Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OhioKelli K Ryckman - Departments of Epidemiology and Pediatrics, College of Public Health and Carver College of Medicine, University of Iowa, Iowa City, IowaTina V Hartert - Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn
- Resource Type
- Journal article
- Publication Details
- Journal of allergy and clinical immunology, Vol.141(4), pp.1191-1201
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.jaci.2017.04.021
- PMID
- 28479327
- PMCID
- PMC5671382
- ISSN
- 0091-6749
- eISSN
- 1097-6825
- Grant note
- U19AI95227; K24 AI 77930; R21HD087864; T32HL087738 / National Institutes of Health (http://dx.doi.org/10.13039/100000002)
- Language
- English
- Date published
- 04/2018
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology
- Record Identifier
- 9983995122902771
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