Journal article
A role for dystrophin-associated glycoproteins and utrophin in agrin-induced AChR clustering
Cell (Cambridge), Vol.77(5), pp.663-674
1994
DOI: 10.1016/0092-8674(94)90051-5
PMID: 8205616
Abstract
Synapse formation is characterized by the accumulation of molecules at the site of contact between pre- and postsynaptic cells. Agrin, a protein implicated in the regulation of this process, causes the clustering of acetylcholine receptors (AChRs). Here we characterize an agrin-binding site on the surface of muscle cells, show that this site corresponds to α-dystroglycan, and present evidence that α-dystroglycan is functionally related to agrin activity. Furthermore, we demonstrate that α-dystroglycan and adhalln, components of the dystrophin-associated glycoprotein complex, as well as utrophin, colocalize with agrin-induced AChR clusters. Thus, agrin may function by initiating or stabilizing a synapse-specific membrane cytoskeleton that in turn serves as a scaffold upon which synaptic molecules are concentrated.
Details
- Title: Subtitle
- A role for dystrophin-associated glycoproteins and utrophin in agrin-induced AChR clustering
- Creators
- James T Campanelll - Howard Hughes Medical Institute Department of Molecular and Cellular Physiology Stanford University Stanford, California 94305 USASteven L Roberds - Howard Hughes Medical Institute Department of Physiology and Biophysics University of Iowa College of Medicine Iowa City, Iowa 52242 USAKevin P Campbell - Howard Hughes Medical Institute Department of Physiology and Biophysics University of Iowa College of Medicine Iowa City, Iowa 52242 USARichard H Scheller - Howard Hughes Medical Institute Department of Molecular and Cellular Physiology Stanford University Stanford, California 94305 USA
- Resource Type
- Journal article
- Publication Details
- Cell (Cambridge), Vol.77(5), pp.663-674
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0092-8674(94)90051-5
- PMID
- 8205616
- ISSN
- 0092-8674
- eISSN
- 1097-4172
- Language
- English
- Date published
- 1994
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute
- Record Identifier
- 9984020882202771
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