Journal article
A selective delta opioid receptor antagonist based on a stilbene core
Bioorganic & medicinal chemistry letters, Vol.25(23), pp.5532-5535
12/01/2015
DOI: 10.1016/j.bmcl.2015.10.059
PMCID: PMC4645280
PMID: 26525865
Abstract
[Display omitted] Studies of directed ortho metalation reactions on an aromatic substrate with multiple potential directing groups have identified conditions that favor either of two regioisomers. One of these regioisomers has been converted to an analogue of the stilbene pawhuskin A, and been shown to have high selectivity as an antagonist of the delta opioid receptor. Docking studies have suggested that this compound can adopt a conformation similar to naltrindole, a known delta antagonist.
Details
- Title: Subtitle
- A selective delta opioid receptor antagonist based on a stilbene core
- Creators
- Alyssa M Hartung - Department of Chemistry, The University of Iowa, Chemistry Building, Iowa City, IA 52242-1294, United StatesHernan A Navarro - Discovery Sciences, RTI International, Research Triangle Park, NC 27709, United StatesDavid F Wiemer - Department of Chemistry, The University of Iowa, Chemistry Building, Iowa City, IA 52242-1294, United StatesJeffrey D Neighbors - Department of Chemistry, The University of Iowa, Chemistry Building, Iowa City, IA 52242-1294, United States
- Resource Type
- Journal article
- Publication Details
- Bioorganic & medicinal chemistry letters, Vol.25(23), pp.5532-5535
- DOI
- 10.1016/j.bmcl.2015.10.059
- PMID
- 26525865
- PMCID
- PMC4645280
- NLM abbreviation
- Bioorg Med Chem Lett
- ISSN
- 0960-894X
- eISSN
- 1464-3405
- Publisher
- Elsevier Ltd
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: DA02-6573
- Language
- English
- Date published
- 12/01/2015
- Academic Unit
- Neuroscience and Pharmacology; Chemistry
- Record Identifier
- 9983985826702771
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