A selective role for right insula—basal ganglia circuits in appetitive stimulus processing

Lavanya Vijayaraghavan; Ralph Adolphs; Daniel P Kennedy; Martin Cassell; Daniel Tranel; Sergio Paradiso

doi:10.1093/scan/nss077

Back

A selective role for right insula—basal ganglia circuits in appetitive stimulus processing

Journal article

Open access

A selective role for right insula—basal ganglia circuits in appetitive stimulus processing

Lavanya Vijayaraghavan, Ralph Adolphs, Daniel P Kennedy, Martin Cassell, Daniel Tranel and Sergio Paradiso

Social cognitive and affective neuroscience, Vol.8(7), pp.813-819

10/2013

DOI: 10.1093/scan/nss077

PMCID: PMC3791073

PMID: 22798397

Files and links (1)

url

https://doi.org/10.1093/scan/nss077View

Published (Version of record) Open Access

Abstract

Hemispheric lateralization of hedonic evaluation (‘liking’) and incentive motivation (‘wanting’) in neural networks connecting the basal ganglia and insula (BG-I) in humans was examined. Participants with brain damage restricted to the BG-I of the right ( n = 5) or left ( n = 5) hemisphere, and 26 healthy participants matched on age, sex and intelligence quotient were tested on positively and negatively valenced pictures drawn from varied stimulus categories (Vijayaraghavan et al. , 2008). Liking was assessed with explicit ratings of pleasantness using a nine-point Likert scale. Wanting was quantified as the amount of work (via repeated keypresses) that participants expended to increase (approach) or decrease (withdraw) viewing time. Right-lesion patients showed abnormally low viewing times and liking ratings for positive images. For a subset of positive images depicting sexual content, right-lesion patients exhibited active withdrawal, while the other two groups approached such stimuli. These results suggest that the right basal ganglia–insula complex plays a greater role than the left in supporting hedonic evaluation and motivational approach to positively valenced stimuli. The finding that active avoidance of stimuli that were not ‘liked’ was spared in both right- and left-sided lesion subjects suggests that unilateral damage to insula/basal ganglia circuits may not be sufficient to affect general incentive motivation independent of preference.

hedonic evaluation

incentive motivation

basal ganglia

emotion

insula

Original

Details

Title: Subtitle: A selective role for right insula—basal ganglia circuits in appetitive stimulus processing
Creators: Lavanya Vijayaraghavan - Department of Psychiatry, University of Iowa, IA, USA
Ralph Adolphs - Department of Psychiatry, University of Iowa, IA, USA
Daniel P Kennedy - Department of Psychiatry, University of Iowa, IA, USA
Martin Cassell - Department of Psychiatry, University of Iowa, IA, USA
Daniel Tranel - Department of Psychiatry, University of Iowa, IA, USA
Sergio Paradiso - Department of Psychiatry, University of Iowa, IA, USA
Resource Type: Journal article
Publication Details: Social cognitive and affective neuroscience, Vol.8(7), pp.813-819
DOI: 10.1093/scan/nss077
PMID: 22798397
PMCID: PMC3791073
NLM abbreviation: Soc Cogn Affect Neurosci
ISSN: 1749-5016
eISSN: 1749-5024
Publisher: Oxford University Press
Language: English
Date published: 10/2013
Academic Unit: Neurology; Anatomy and Cell Biology; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984002450302771

Metrics

60 Record Views

9 Times Cited - Web of Science